Neuroendocrine carcinoma of gallbladder: a case series and literature review

Neuroendocrine carcinoma (NEC) of gallbladder is a rare tumor. The clinical manifestation, treatment, and prognosis of gallbladder NEC are rarely reported. Eight gallbladder NEC patients were admitted into our hospital. The major complaint was right upper quadrant pain. Two patients underwent a radi...

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Bibliographic Details
Published in:European journal of medical research 2019-02, Vol.24 (1), p.8-8, Article 8
Main Authors: Liu, Wei, Chen, Weijie, Chen, Jiemin, Hong, Tao, Li, Binglu, Qu, Qiang, He, Xiaodong
Format: Article
Language:English
Subjects:
Cancer
Cancer treatment
Carcinoma
Case Report
Case studies
Chemotherapy
Cholecystectomy
Dissection
Edema
Gallbladder
Gallbladder diseases
Jaundice
Laparoscopy
Literature reviews
Liver
Medical prognosis
Neuroendocrine carcinoma
Neuroendocrine tumor
Neuroendocrine tumors
Pain
Patients
Surgery
Therapeutics
Tumors
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Summary:Neuroendocrine carcinoma (NEC) of gallbladder is a rare tumor. The clinical manifestation, treatment, and prognosis of gallbladder NEC are rarely reported. Eight gallbladder NEC patients were admitted into our hospital. The major complaint was right upper quadrant pain. Two patients underwent a radical resection of gallbladder and liver quadrate lobe. One of them underwent chemotherapies and had no recurrence of NEC during a 25-month followed-up period. The other patient did not undergo chemotherapies, and the NEC recurred in the patient 15 months afterwards. Two patients underwent a radical resection of gallbladder. One of them underwent chemotherapies and had an NEC recurrence 12 months afterwards. The other patient did not undergo chemotherapies and died due to the NEC recurrence 5 months after surgery. Three patients underwent a laparoscopic cholecystectomy and pathologic result showed gallbladder NEC. They did not undergo further treatment and no NEC recurrence was found. One patient underwent tumor biopsy and died due to obstructive jaundice 3 months afterwards. Pathologic results showed that all cases had positive chromogranin A and synaptophysin staining. Gallbladder NEC showed no noticeably specific features, and the diagnosis relied on the pathological and immunohistochemistrical results. For T1N0M0 gallbladder NEC, cholecystectomy might be enough. For patients in a late stage, the management of combined therapies might be optimal.
ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/s40001-019-0363-z