Chronic lymphocytic lymphoma and concomitant renal cell carcinoma (Clear Cell Type): Review of the literature

Abstract In the present report, a 73 years-old male patient who developed clear cell type renal cell carcinoma (RCC) 5 years after the diagnosis of chronic lymphocytic lymphoma (CLL) and plausible explanations for this association were discussed by the authors. The incidence of CLL and RCC occurring...

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Bibliographic Details
Published in:Leukemia research reports 2016, Vol.6 (C), p.8-10
Main Authors: Uz, Burak, Dolasik, Ilhan, Ucer, Ozlem, Dagli, Adile Ferda, Simsek, Sercan
Format: Article
Language:English
Subjects:
Chronic lymphocytic lymphoma
Hematology, Oncology and Palliative Medicine
Pathology
Renal cell carcinoma
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Summary:Abstract In the present report, a 73 years-old male patient who developed clear cell type renal cell carcinoma (RCC) 5 years after the diagnosis of chronic lymphocytic lymphoma (CLL) and plausible explanations for this association were discussed by the authors. The incidence of CLL and RCC occurring in the same patient is higher than that expected in the general population. Various explicative hypotheses of this concurrence include treatment-related development of a second malignancy, immunomodulatory mechanisms, viral aetiology, cytokine (interleukin 6) release from a tumor, and common genetic mutations. Further investigations are warranted.
ISSN:2213-0489
2213-0489
DOI:10.1016/j.lrr.2016.06.002