Immune‐mediated thrombotic thrombocytopenic purpura prognosis is affected by blood pressure

The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypic...

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Published in:Research and practice in thrombosis and haemostasis 2022-05, Vol.6 (4), p.e12702-n/a, Article e12702
Main Authors: Joseph, Adrien, Eloit, Martin, Azoulay, Elie, Kaplanski, Gilles, Provot, François, Presne, Claire, Wynckel, Alain, Grangé, Steven, Rondeau, Éric, Pène, Frédéric, Delmas, Yahsou, Lautrette, Alexandre, Barbet, Christelle, Mousson, Christiane, Coindre, Jean‐Philippe, Perez, Pierre, Jamme, Matthieu, Augusto, Jean‐François, Poullin, Pascale, Jacobs, Frédéric, El Karoui, Khalil, Vigneau, Cécile, Ulrich, Marc, Kanouni, Tarik, Le Quintrec, Moglie, Hamidou, Mohamed, Ville, Simon, Charvet‐Rumpler, Anne, Ojeda‐Uribe, Mario, Godmer, Pascal, Fremeaux‐Bacchi, Véronique, Veyradier, Agnès, Halimi, Jean‐Michel, Coppo, Paul
Format: Article
Language:English
Subjects:
ADAMTS13
Anemia
Blood platelets
Blood pressure
Brief Report
Brief Reports
complement
Creatinine
Hematology
Hemoglobin
hemolytic uremic syndrome
Human health and pathology
Hypertension
Kidney diseases
Life Sciences
Medical prognosis
Patients
prognosis
Purpura
Thrombocytopenia
thrombotic microangiopathies
thrombotic thrombocytopenic purpura
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Summary:The prevalence, prognostic role, and diagnostic value of blood pressure in immune‐mediated thrombotic thrombocytopenic purpura (iTTP) and other thrombotic microangiopathies (TMAs) remain unclear. Using a national cohort of iTTP (n = 368), Shigatoxin‐induced hemolytic uremic syndrome (n = 86), atypical hemolytic uremic syndrome (n = 84), and hypertension‐related thrombotic microangiopathy (n = 25), we sought to compare the cohort’s blood pressure profile to assess its impact on prognosis and diagnostic performances. Patients with iTTP had lower blood pressure than patients with other TMAs, systolic (130 [interquartile range (IQR) 118–143] vs 161 [IQR 142–180] mmHg) and diastolic (76 [IQR 69–83] vs 92 [IQR 79–105] mmHg, both p 
ISSN:2475-0379
2475-0379
DOI:10.1002/rth2.12702