Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases

The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous...

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Published in:Journal of Parasitology Research 2012, Vol.2012 (2012), p.297-305
Main Authors: de Meis, Juliana, Aurélio Farias-de-Oliveira, Désio, Nunes Panzenhagen, Pedro H., Maran, Naiara, Villa-Verde, Déa Maria Serra, Morrot, Alexandre, Savino, Wilson
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cited_by cdi_FETCH-LOGICAL-a4880-fd9c15956c984df209aa5a0b6792f6388239f1c4293509098ff7b16258205ded3
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container_end_page 305
container_issue 2012
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container_title Journal of Parasitology Research
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creator de Meis, Juliana
Aurélio Farias-de-Oliveira, Désio
Nunes Panzenhagen, Pedro H.
Maran, Naiara
Villa-Verde, Déa Maria Serra
Morrot, Alexandre
Savino, Wilson
description The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs. This organ can undergo atrophy, caused by several endogenous and exogenous factors such as ageing, hormone fluctuations, and infectious agents. This paper will focus on emerging data on the thymic atrophy caused by infectious agents. We present data on the dynamics of thymus lymphocytes during acute Trypanosoma cruzi infection, showing that the resulting thymus atrophy comprises the abnormal release of thymic-derived T cells and may have an impact on host immune response.
doi_str_mv 10.1155/2012/574020
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title Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases
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