Inhalation Delivery for the Treatment and Prevention of COVID-19 Infection

Coronavirus disease-2019 (COVID-19) is caused by coronavirus-2 (SARS-CoV-2) and has produced a global pandemic. As of 22 June 2021, 178 million people have been affected worldwide, and 3.87 million people have died from COVID-19. According to the Centers for Disease Control and Prevention (CDC) of t...

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Bibliographic Details
Published in:Pharmaceutics 2021-07, Vol.13 (7), p.1077
Main Authors: Eedara, Basanth Babu, Alabsi, Wafaa, Encinas-Basurto, David, Polt, Robin, Ledford, Julie G, Mansour, Heidi M
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
clinical status
Coronaviruses
COVID-19
inhalation delivery
inhalation therapeutics
Middle East respiratory syndrome
respiratory vaccines
Review
Viruses
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Summary:Coronavirus disease-2019 (COVID-19) is caused by coronavirus-2 (SARS-CoV-2) and has produced a global pandemic. As of 22 June 2021, 178 million people have been affected worldwide, and 3.87 million people have died from COVID-19. According to the Centers for Disease Control and Prevention (CDC) of the United States, COVID-19 virus is primarily transmitted between people through respiratory droplets and contact routes. Since the location of initial infection and disease progression is primarily through the lungs, the inhalation delivery of drugs directly to the lungs may be the most appropriate route of administration for treating COVID-19. This review article aims to present possible inhalation therapeutics and vaccines for the treatment of COVID-19 symptoms. This review covers the comparison between SARS-CoV-2 and other coronaviruses such as SARS-CoV/MERS, inhalation therapeutics for the treatment of COVID-19 symptoms, and vaccines for preventing infection, as well as the current clinical status of inhaled therapeutics and vaccines.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics13071077