Parallel processing of working memory and temporal information by distinct types of cortical projection neurons

It is unclear how different types of cortical projection neurons work together to support diverse cortical functions. We examined the discharge characteristics and inactivation effects of intratelencephalic (IT) and pyramidal tract (PT) neurons—two major types of cortical excitatory neurons that pro...

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Published in:Nature communications 2021-07, Vol.12 (1), p.4352-4352, Article 4352
Main Authors: Bae, Jung Won, Jeong, Huijeong, Yoon, Young Ju, Bae, Chan Mee, Lee, Hyeonsu, Paik, Se-Bum, Jung, Min Whan
Format: Article
Language:English
Subjects:
14/34
631/378/1595/1636
631/378/1595/2618
631/378/3920
64/60
82/1
82/51
9/10
Animals
Behavior, Animal - physiology
Cortex (temporal)
Deactivation
Delayed response
Division of labor
Gene Knock-In Techniques
Humanities and Social Sciences
Inactivation
Interneurons - physiology
Maintenance
Memory
Memory, Short-Term - physiology
Mice
Mice, Transgenic
multidisciplinary
Neurons
Neurons - physiology
Neurophysiology
Optogenetics
Parallel processing
Prefrontal cortex
Prefrontal Cortex - physiology
Principal Component Analysis
Projection
Pyramidal cells
Pyramidal Cells - physiology
Science
Science (multidisciplinary)
Short term memory
Time Factors
Tracking
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description It is unclear how different types of cortical projection neurons work together to support diverse cortical functions. We examined the discharge characteristics and inactivation effects of intratelencephalic (IT) and pyramidal tract (PT) neurons—two major types of cortical excitatory neurons that project to cortical and subcortical structures, respectively—in the deep layer of the medial prefrontal cortex in mice performing a delayed response task. We found stronger target-dependent firing of IT than PT neurons during the delay period. We also found the inactivation of IT neurons, but not PT neurons, impairs behavioral performance. In contrast, PT neurons carry more temporal information than IT neurons during the delay period. Our results indicate a division of labor between IT and PT projection neurons in the prefrontal cortex for the maintenance of working memory and for tracking the passage of time, respectively. Intratelencephalic and pyramidal tract neurons are two major types of cortical excitatory neurons that project to cortical and subcortical structures. The authors show that in the prefrontal cortex the two populations have different roles for the maintenance of working memory and for tracking the passage of time.
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subjects 14/34
631/378/1595/1636
631/378/1595/2618
631/378/3920
64/60
82/1
82/51
9/10
Animals
Behavior, Animal - physiology
Cortex (temporal)
Deactivation
Delayed response
Division of labor
Gene Knock-In Techniques
Humanities and Social Sciences
Inactivation
Interneurons - physiology
Maintenance
Memory
Memory, Short-Term - physiology
Mice
Mice, Transgenic
multidisciplinary
Neurons
Neurons - physiology
Neurophysiology
Optogenetics
Parallel processing
Prefrontal cortex
Prefrontal Cortex - physiology
Principal Component Analysis
Projection
Pyramidal cells
Pyramidal Cells - physiology
Science
Science (multidisciplinary)
Short term memory
Time Factors
Tracking
title Parallel processing of working memory and temporal information by distinct types of cortical projection neurons
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