Hemiacetalmeroterpenoids A–C and Astellolide Q with Antimicrobial Activity from the Marine-Derived Fungus Penicillium sp. N-5

Four new compounds including three andrastin-type meroterpenoids hemiacetalmeroterpenoids A-C (1–3), and a drimane sesquiterpenoid astellolide Q (15), together with eleven known compounds (4–14) were isolated from the cultures of the marine-derived fungus Penicillium sp. N-5, while compound 14 was f...

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Bibliographic Details
Published in:Marine drugs 2022-08, Vol.20 (8), p.514
Main Authors: Chen, Tao, Yang, Wencong, Li, Taobo, Yin, Yihao, Liu, Yufeng, Wang, Bo, She, Zhigang
Format: Article
Language:English
Subjects:
Absolute configuration
andrastin-type meroterpenoids
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
antimicrobials activities
Carbon
Configurations
Disease resistance
drimane sesquiterpenoid
Fungi
marine-derived fungus
Metabolites
Penicillium
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Summary:Four new compounds including three andrastin-type meroterpenoids hemiacetalmeroterpenoids A-C (1–3), and a drimane sesquiterpenoid astellolide Q (15), together with eleven known compounds (4–14) were isolated from the cultures of the marine-derived fungus Penicillium sp. N-5, while compound 14 was first isolated from a natural source. The structures of the new compounds were determined by analysis of detailed spectroscopic data, and the absolute configurations were further decided by a comparison of the experimental and calculated ECD spectra. Hemiacetalmeroterpenoid A (1) possesses a unique and highly congested 6,6,6,6,5,5-hexa-cyclic skeleton. Moreover, the absolute configuration of compound 14 was also reported for the first time. Compounds 1, 5 and 10 exhibited significant antimicrobial activities against Penicillium italicum and Colletrichum gloeosporioides with MIC values ranging from 1.56 to 6.25 μg/mL.
ISSN:1660-3397
1660-3397
DOI:10.3390/md20080514