Renal arterial resistive index as a prognostic marker in lupus nephritis patients

• Published in: Nefrología 2024-05, Vol.44 (3), p.373-381
• Main Authors: Abdul Hamid, Samir Kamal, Elshazly, Ashraf, Faisal, Yasser Abd Elmawgood, M.saleh, Kawsar Abdel Halim, Aly, Mai Mostafa
• Format: Article
• Language: English
• Subjects: Adult; Biopsia renal; Female; Humans; Kidney - diagnostic imaging; Kidney - pathology; Kidney - physiopathology; Kidney biopsy; Lupus nephritis; Lupus Nephritis - diagnostic imaging; Lupus Nephritis - physiopathology; Male; Middle Aged; Nefritis lúpica; Prognosis; Renal Artery - diagnostic imaging; Renal Artery - physiopathology; Renal resistive index; Vascular Resistance; Young Adult; Índice de resistencia renal
• ISSN: 0211-6995; 2013-2514
• DOI: 10.1016/j.nefro.2023.07.003

Lupus nephritis (LN) is known to be one of the most serious complications of SLE and it is a major predictor of poor prognosis. Despite the improvement in understanding the pathophysiology of lupus nephritis and greater improvement in diagnostic approaches, lupus nephritis patients have poorer outcomes. Study the relation between renal resistive index (RRI) and renal function and histopathological parameters in lupus nephritis (LN) patients. Also to investigate the usefulness of RRI in predicting response to treatment. This study included 126 patients who were split into two groups (group 1: 101 LN patients and group 2: 25 SLE patients without renal affection); and 100 healthy controls (group 3). The RRI was measured for all participants through a colored Doppler ultrasound examination. LN patients underwent renal biopsy and received their therapy and were followed up for 6 months. The RRI was significantly greater in the LN group (mean±SD; 0.64±0.07) than in SLE patients without nephritis (0.5884±0.04) (P