Epigenome-wide association study of dietary fatty acid intake

Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often reported to be associated with inflammation-related traits. The effect of PUFAs on health ou...

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Published in:Clinical epigenetics 2024-02, Vol.16 (1), p.29-29, Article 29
Main Authors: Lange de Luna, Julia, Nounu, Aayah, Neumeyer, Sonja, Sinke, Lucy, Wilson, Rory, Hellbach, Fabian, Matías-García, Pamela R, Delerue, Thomas, Winkelmann, Juliane, Peters, Annette, Thorand, Barbara, Beekman, Marian, Heijmans, Bastiaan T, Slagboom, Eline, Gieger, Christian, Linseisen, Jakob, Waldenberger, Melanie
Format: Article
Language:English
Subjects:
Analysis
Biotechnology industry
Cardiovascular disease
Cardiovascular diseases
Cell cycle
Chronic illnesses
CpG islands
Diabetes
Diabetes mellitus
Dietary intake
DNA methylation
Docosahexaenoic acid
Docosapentaenoic acid
Eicosapentaenoic acid
Epigenetics
EWAS
Fatty acids
Health aspects
Inflammation
Insulin
Kinases
Lipids
Meta-analysis
Metabolism
Methylation
Omega-3 fatty acids
Overweight
Polyunsaturated fatty acids
Population studies
Protein-serine/threonine kinase
Proteins
PUFA n-3
PUFA n-6
Rheumatoid arthritis
Tumor necrosis factor-TNF
Type 2 diabetes
Unsaturated fatty acids
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Summary:Dietary intake of n-3 polyunsaturated fatty acids (PUFA) may have a protective effect on the development of cardiovascular diseases, diabetes, depression and cancer, while a high intake of n-6 PUFA was often reported to be associated with inflammation-related traits. The effect of PUFAs on health outcomes might be mediated by DNA methylation (DNAm). The aim of our study is to identify the impact of PUFA intake on DNAm in the Cooperative Health Research in the Region of Augsburg (KORA) FF4 cohort and the Leiden Longevity Study (LLS). DNA methylation levels were measured in whole blood from the population-based KORA FF4 study (N = 1354) and LLS (N = 448), using the Illumina MethylationEPIC BeadChip and Illumina HumanMethylation450 array, respectively. We assessed associations between DNAm and intake of eight and four PUFAs in KORA and LLS, respectively. Where possible, results were meta-analyzed. Below the Bonferroni correction threshold (p 
ISSN:1868-7083
1868-7075
1868-7083
1868-7075
DOI:10.1186/s13148-024-01643-9