Loading…
An Update on S100A16 in Human Cancer
S100A16 is a member of the S100 protein family. S100A16 is expressed in a variety of human tissues, although at varying levels. S100A16 expression is especially high in tissues rich in epithelial cells. mRNA and protein levels of S100A16 have been reported to be differentially expressed in the major...
Saved in:
| Published in: | Biomolecules (Basel, Switzerland) Switzerland), 2023-07, Vol.13 (7), p.1070 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c571t-87db8b39e54af104510b8ecf821f57a4a0e32d8354b445627d6be3042909fbb83 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c571t-87db8b39e54af104510b8ecf821f57a4a0e32d8354b445627d6be3042909fbb83 |
| container_end_page | |
| container_issue | 7 |
| container_start_page | 1070 |
| container_title | Biomolecules (Basel, Switzerland) |
| container_volume | 13 |
| creator | Basnet, Suyog Vallenari, Evan Michael Maharjan, Urusha Sharma, Sunita Schreurs, Olaf Sapkota, Dipak |
| description | S100A16 is a member of the S100 protein family. S100A16 is expressed in a variety of human tissues, although at varying levels. S100A16 expression is especially high in tissues rich in epithelial cells. mRNA and protein levels of S100A16 have been reported to be differentially expressed in the majority of human cancers. Functionally, S100A16 has been linked to several aspects of tumorigenesis, for example, cell proliferation, differentiation, migration, invasion, and epithelial-mesenchymal transition (EMT). Accordingly, S100A16 has been suggested to have both tumour-promoting and suppressive roles in human cancers. S100A16-mediated cellular functions are suggested to be mediated by the regulation of various signaling pathways/proteins including EMT-related proteins E-cadherin and Vimentin, PI3K-AKT, p53, MMP1-1, MMP-2, MMP-9, JNK/p38, etc. In addition to the functional roles, expression of S100A16 has been suggested to have prognostic potential in various cancer types. The aims of this review are to summarise the expression profile, identify common molecular partners and functional roles, and explore the prognostic potential of S100A16 in human cancers. |
| doi_str_mv | 10.3390/biom13071070 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_0c6a5286ea554f7f8de17593266d69e0</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A758880053</galeid><doaj_id>oai_doaj_org_article_0c6a5286ea554f7f8de17593266d69e0</doaj_id><sourcerecordid>A758880053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c571t-87db8b39e54af104510b8ecf821f57a4a0e32d8354b445627d6be3042909fbb83</originalsourceid><addsrcrecordid>eNptUt9rFDEQXkSxpfbNZ1nQBx-8OvmdfZLjsLZQ8EELvoVsdnLm2E3O7G7B_95cr613YiYkYebLl5kvU1WvCVww1sDHNqSBMFAEFDyrTiklekEV-_H84HxSnY_jBsrQZVL2sjphSkBDQJ5W75axvt12dsI6xfobAVgSWYdYX82DjfXKRof5VfXC237E84f9rLq9_Px9dbW4-frlerW8WTihyLTQqmt1yxoU3HoCXBBoNTqvKfFCWW4BGe00E7zlXEiqOtkiA04baHzbanZWXe95u2Q3ZpvDYPNvk2ww946U18bmKbgeDThpBdUSrRDcK687JEo0jErZyQahcH3ac23ndsDOYZyy7Y9IjyMx_DTrdGcIMKVAqMJQ7xlcDuMUookp2xLWgpaVKrJL-P3DIzn9mnGczBBGh31vI6Z5NFRzXiSXvCnQt_9AN2nOsci5Q9FGyWJ_UWtbigzRp5Kb25GapRJalx8UrKAu_oMq1uEQXIroQ_EfXfjwWEoax4z-SQcCZtdI5rCRCvzNoXZP4Me2YX8Ar-G7eQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2842976767</pqid></control><display><type>article</type><title>An Update on S100A16 in Human Cancer</title><source>NORA - Norwegian Open Research Archives</source><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Basnet, Suyog ; Vallenari, Evan Michael ; Maharjan, Urusha ; Sharma, Sunita ; Schreurs, Olaf ; Sapkota, Dipak</creator><creatorcontrib>Basnet, Suyog ; Vallenari, Evan Michael ; Maharjan, Urusha ; Sharma, Sunita ; Schreurs, Olaf ; Sapkota, Dipak</creatorcontrib><description>S100A16 is a member of the S100 protein family. S100A16 is expressed in a variety of human tissues, although at varying levels. S100A16 expression is especially high in tissues rich in epithelial cells. mRNA and protein levels of S100A16 have been reported to be differentially expressed in the majority of human cancers. Functionally, S100A16 has been linked to several aspects of tumorigenesis, for example, cell proliferation, differentiation, migration, invasion, and epithelial-mesenchymal transition (EMT). Accordingly, S100A16 has been suggested to have both tumour-promoting and suppressive roles in human cancers. S100A16-mediated cellular functions are suggested to be mediated by the regulation of various signaling pathways/proteins including EMT-related proteins E-cadherin and Vimentin, PI3K-AKT, p53, MMP1-1, MMP-2, MMP-9, JNK/p38, etc. In addition to the functional roles, expression of S100A16 has been suggested to have prognostic potential in various cancer types. The aims of this review are to summarise the expression profile, identify common molecular partners and functional roles, and explore the prognostic potential of S100A16 in human cancers.</description><identifier>ISSN: 2218-273X</identifier><identifier>EISSN: 2218-273X</identifier><identifier>DOI: 10.3390/biom13071070</identifier><identifier>PMID: 37509106</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>1-Phosphatidylinositol 3-kinase ; AKT protein ; Amino acids ; Binding sites ; biomarkers ; Calcium-binding proteins ; Cancer ; Cell differentiation ; Cell migration ; Cell proliferation ; Cellular control mechanisms ; Development and progression ; E-cadherin ; EMT ; Epithelial cells ; Gastric cancer ; Gelatinase A ; Gelatinase B ; Genetic aspects ; Health aspects ; invasion ; Lung cancer ; Medical prognosis ; mRNA ; p53 Protein ; prognosis ; proliferation ; Proteins ; Review ; Risk factors ; S100 ; S100 protein ; Tumorigenesis ; Vimentin</subject><ispartof>Biomolecules (Basel, Switzerland), 2023-07, Vol.13 (7), p.1070</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-87db8b39e54af104510b8ecf821f57a4a0e32d8354b445627d6be3042909fbb83</citedby><cites>FETCH-LOGICAL-c571t-87db8b39e54af104510b8ecf821f57a4a0e32d8354b445627d6be3042909fbb83</cites><orcidid>0000-0003-4852-8608 ; 0009-0001-2765-9150 ; 0000-0003-0061-825X ; 0000-0003-2536-9659</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2842976767/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2842976767?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,26567,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37509106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Basnet, Suyog</creatorcontrib><creatorcontrib>Vallenari, Evan Michael</creatorcontrib><creatorcontrib>Maharjan, Urusha</creatorcontrib><creatorcontrib>Sharma, Sunita</creatorcontrib><creatorcontrib>Schreurs, Olaf</creatorcontrib><creatorcontrib>Sapkota, Dipak</creatorcontrib><title>An Update on S100A16 in Human Cancer</title><title>Biomolecules (Basel, Switzerland)</title><addtitle>Biomolecules</addtitle><description>S100A16 is a member of the S100 protein family. S100A16 is expressed in a variety of human tissues, although at varying levels. S100A16 expression is especially high in tissues rich in epithelial cells. mRNA and protein levels of S100A16 have been reported to be differentially expressed in the majority of human cancers. Functionally, S100A16 has been linked to several aspects of tumorigenesis, for example, cell proliferation, differentiation, migration, invasion, and epithelial-mesenchymal transition (EMT). Accordingly, S100A16 has been suggested to have both tumour-promoting and suppressive roles in human cancers. S100A16-mediated cellular functions are suggested to be mediated by the regulation of various signaling pathways/proteins including EMT-related proteins E-cadherin and Vimentin, PI3K-AKT, p53, MMP1-1, MMP-2, MMP-9, JNK/p38, etc. In addition to the functional roles, expression of S100A16 has been suggested to have prognostic potential in various cancer types. The aims of this review are to summarise the expression profile, identify common molecular partners and functional roles, and explore the prognostic potential of S100A16 in human cancers.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>AKT protein</subject><subject>Amino acids</subject><subject>Binding sites</subject><subject>biomarkers</subject><subject>Calcium-binding proteins</subject><subject>Cancer</subject><subject>Cell differentiation</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Cellular control mechanisms</subject><subject>Development and progression</subject><subject>E-cadherin</subject><subject>EMT</subject><subject>Epithelial cells</subject><subject>Gastric cancer</subject><subject>Gelatinase A</subject><subject>Gelatinase B</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>invasion</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>mRNA</subject><subject>p53 Protein</subject><subject>prognosis</subject><subject>proliferation</subject><subject>Proteins</subject><subject>Review</subject><subject>Risk factors</subject><subject>S100</subject><subject>S100 protein</subject><subject>Tumorigenesis</subject><subject>Vimentin</subject><issn>2218-273X</issn><issn>2218-273X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>3HK</sourceid><sourceid>DOA</sourceid><recordid>eNptUt9rFDEQXkSxpfbNZ1nQBx-8OvmdfZLjsLZQ8EELvoVsdnLm2E3O7G7B_95cr613YiYkYebLl5kvU1WvCVww1sDHNqSBMFAEFDyrTiklekEV-_H84HxSnY_jBsrQZVL2sjphSkBDQJ5W75axvt12dsI6xfobAVgSWYdYX82DjfXKRof5VfXC237E84f9rLq9_Px9dbW4-frlerW8WTihyLTQqmt1yxoU3HoCXBBoNTqvKfFCWW4BGe00E7zlXEiqOtkiA04baHzbanZWXe95u2Q3ZpvDYPNvk2ww946U18bmKbgeDThpBdUSrRDcK687JEo0jErZyQahcH3ac23ndsDOYZyy7Y9IjyMx_DTrdGcIMKVAqMJQ7xlcDuMUookp2xLWgpaVKrJL-P3DIzn9mnGczBBGh31vI6Z5NFRzXiSXvCnQt_9AN2nOsci5Q9FGyWJ_UWtbigzRp5Kb25GapRJalx8UrKAu_oMq1uEQXIroQ_EfXfjwWEoax4z-SQcCZtdI5rCRCvzNoXZP4Me2YX8Ar-G7eQ</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Basnet, Suyog</creator><creator>Vallenari, Evan Michael</creator><creator>Maharjan, Urusha</creator><creator>Sharma, Sunita</creator><creator>Schreurs, Olaf</creator><creator>Sapkota, Dipak</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>3HK</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4852-8608</orcidid><orcidid>https://orcid.org/0009-0001-2765-9150</orcidid><orcidid>https://orcid.org/0000-0003-0061-825X</orcidid><orcidid>https://orcid.org/0000-0003-2536-9659</orcidid></search><sort><creationdate>20230701</creationdate><title>An Update on S100A16 in Human Cancer</title><author>Basnet, Suyog ; Vallenari, Evan Michael ; Maharjan, Urusha ; Sharma, Sunita ; Schreurs, Olaf ; Sapkota, Dipak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-87db8b39e54af104510b8ecf821f57a4a0e32d8354b445627d6be3042909fbb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>AKT protein</topic><topic>Amino acids</topic><topic>Binding sites</topic><topic>biomarkers</topic><topic>Calcium-binding proteins</topic><topic>Cancer</topic><topic>Cell differentiation</topic><topic>Cell migration</topic><topic>Cell proliferation</topic><topic>Cellular control mechanisms</topic><topic>Development and progression</topic><topic>E-cadherin</topic><topic>EMT</topic><topic>Epithelial cells</topic><topic>Gastric cancer</topic><topic>Gelatinase A</topic><topic>Gelatinase B</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>invasion</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>mRNA</topic><topic>p53 Protein</topic><topic>prognosis</topic><topic>proliferation</topic><topic>Proteins</topic><topic>Review</topic><topic>Risk factors</topic><topic>S100</topic><topic>S100 protein</topic><topic>Tumorigenesis</topic><topic>Vimentin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Basnet, Suyog</creatorcontrib><creatorcontrib>Vallenari, Evan Michael</creatorcontrib><creatorcontrib>Maharjan, Urusha</creatorcontrib><creatorcontrib>Sharma, Sunita</creatorcontrib><creatorcontrib>Schreurs, Olaf</creatorcontrib><creatorcontrib>Sapkota, Dipak</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Biomolecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Basnet, Suyog</au><au>Vallenari, Evan Michael</au><au>Maharjan, Urusha</au><au>Sharma, Sunita</au><au>Schreurs, Olaf</au><au>Sapkota, Dipak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Update on S100A16 in Human Cancer</atitle><jtitle>Biomolecules (Basel, Switzerland)</jtitle><addtitle>Biomolecules</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>13</volume><issue>7</issue><spage>1070</spage><pages>1070-</pages><issn>2218-273X</issn><eissn>2218-273X</eissn><abstract>S100A16 is a member of the S100 protein family. S100A16 is expressed in a variety of human tissues, although at varying levels. S100A16 expression is especially high in tissues rich in epithelial cells. mRNA and protein levels of S100A16 have been reported to be differentially expressed in the majority of human cancers. Functionally, S100A16 has been linked to several aspects of tumorigenesis, for example, cell proliferation, differentiation, migration, invasion, and epithelial-mesenchymal transition (EMT). Accordingly, S100A16 has been suggested to have both tumour-promoting and suppressive roles in human cancers. S100A16-mediated cellular functions are suggested to be mediated by the regulation of various signaling pathways/proteins including EMT-related proteins E-cadherin and Vimentin, PI3K-AKT, p53, MMP1-1, MMP-2, MMP-9, JNK/p38, etc. In addition to the functional roles, expression of S100A16 has been suggested to have prognostic potential in various cancer types. The aims of this review are to summarise the expression profile, identify common molecular partners and functional roles, and explore the prognostic potential of S100A16 in human cancers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37509106</pmid><doi>10.3390/biom13071070</doi><orcidid>https://orcid.org/0000-0003-4852-8608</orcidid><orcidid>https://orcid.org/0009-0001-2765-9150</orcidid><orcidid>https://orcid.org/0000-0003-0061-825X</orcidid><orcidid>https://orcid.org/0000-0003-2536-9659</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2218-273X |
| ispartof | Biomolecules (Basel, Switzerland), 2023-07, Vol.13 (7), p.1070 |
| issn | 2218-273X 2218-273X |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_0c6a5286ea554f7f8de17593266d69e0 |
| source | NORA - Norwegian Open Research Archives; Publicly Available Content Database; PubMed Central |
| subjects | 1-Phosphatidylinositol 3-kinase AKT protein Amino acids Binding sites biomarkers Calcium-binding proteins Cancer Cell differentiation Cell migration Cell proliferation Cellular control mechanisms Development and progression E-cadherin EMT Epithelial cells Gastric cancer Gelatinase A Gelatinase B Genetic aspects Health aspects invasion Lung cancer Medical prognosis mRNA p53 Protein prognosis proliferation Proteins Review Risk factors S100 S100 protein Tumorigenesis Vimentin |
| title | An Update on S100A16 in Human Cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T16%3A42%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20Update%20on%20S100A16%20in%20Human%20Cancer&rft.jtitle=Biomolecules%20(Basel,%20Switzerland)&rft.au=Basnet,%20Suyog&rft.date=2023-07-01&rft.volume=13&rft.issue=7&rft.spage=1070&rft.pages=1070-&rft.issn=2218-273X&rft.eissn=2218-273X&rft_id=info:doi/10.3390/biom13071070&rft_dat=%3Cgale_doaj_%3EA758880053%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c571t-87db8b39e54af104510b8ecf821f57a4a0e32d8354b445627d6be3042909fbb83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2842976767&rft_id=info:pmid/37509106&rft_galeid=A758880053&rfr_iscdi=true |