MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms

β-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions. Pancreatic β-cell maturity and function are regulated by a variety of transcription factors that enable the adequate expression of the cellular machinery involved in nutrient sensing and commensurate insulin sec...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-03, Vol.12 (4), p.535
Main Authors: Liang, Jiani, Chirikjian, Margot, Pajvani, Utpal B, Bartolomé, Alberto
Format: Article
Language:English
Subjects:
beta cell maturity
Beta cells
Binding sites
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Gene expression
Gene regulation
Glucose
Homeostasis
Humans
Insulin
Insulin - metabolism
Insulin Secretion
Insulin-Secreting Cells - metabolism
Maf Transcription Factors, Large - genetics
Maf Transcription Factors, Large - metabolism
MafA
Metabolism
Mutation
Oxidative stress
pancreatic beta cells
Post-translation
Review
Therapeutic targets
Transcription factors
Translation
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Summary:β-cells are insulin-producing cells in the pancreas that maintain euglycemic conditions. Pancreatic β-cell maturity and function are regulated by a variety of transcription factors that enable the adequate expression of the cellular machinery involved in nutrient sensing and commensurate insulin secretion. One of the key factors in this regulation is MAF bZIP transcription factor A (MafA). MafA expression is decreased in type 2 diabetes, contributing to β-cell dysfunction and disease progression. The molecular biology underlying MafA is complex, with numerous transcriptional and post-translational regulatory nodes. Understanding these complexities may uncover potential therapeutic targets to ameliorate β-cell dysfunction. This article will summarize the role of MafA in normal β-cell function and disease, with a special focus on known transcriptional and post-translational regulators of MafA expression.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12040535