Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. Despite discovering many susceptibility loci, a major proportion of AD genetic variance...

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Bibliographic Details
Published in:Alzheimer's research & therapy 2019-01, Vol.11 (1), p.5-5, Article 5
Main Authors: Nazarian, Alireza, Yashin, Anatoliy I, Kulminski, Alexander M
Format: Article
Language:English
Subjects:
Advertising executives
Aged
Aged, 80 and over
Aging
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Alzheimer's disease
Brain research
Case-Control Studies
Cell adhesion & migration
Cohort Studies
Databases, Factual - trends
Death
Dementia
Disease
Disease susceptibility
Elderly
Female
Gene-based analysis
Genes
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Genetic research
Genetic susceptibility
Genome-wide association study
Genome-Wide Association Study - methods
Genomes
Genomics
Growth factors
Health aspects
Humans
Male
Males
Meta-analysis
Novels
Pathogenesis
Polymorphism, Single Nucleotide - genetics
Proteins
Risk factors
Sex Characteristics
Sex differences (Biology)
Sex disparities
Single nucleotide polymorphisms
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Summary:Alzheimer's disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. Despite discovering many susceptibility loci, a major proportion of AD genetic variance remains to be explained. We investigated the genetic architecture of AD in four publicly available independent datasets through genome-wide association, transcriptome-wide association, and gene-based and pathway-based analyses. To explore differences in the genetic basis of AD between males and females, analyses were performed on three samples in each dataset: males and females combined, only males, or only females. Our genome-wide association analyses corroborated the associations of several previously detected AD loci and revealed novel significant associations of 35 single-nucleotide polymorphisms (SNPs) outside the chromosome 19q13 region at the suggestive significance level of p
ISSN:1758-9193
1758-9193
DOI:10.1186/s13195-018-0458-8