Association Between Age at Diagnosis of Type 2 Diabetes and Cardiovascular Diseases: A Nationwide, Population-Based, Cohort Study

Nationwide studies focusing on the impact of early-onset type 2 diabetes and obesity on the development of cardiovascular diseases (CVD) are limited in China. We aimed to investigate the association between age at diagnosis of type 2 diabetes and the risk of CVD, and to further examine the modifying...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2021-10, Vol.12, p.717069-717069
Main Authors: Hu, Chunyan, Lin, Lin, Zhu, Yujing, Zhang, Yi, Wang, Shuangyuan, Zhang, Jie, Qi, Hongyan, Li, Mian, Zhu, Yuanyue, Huo, Yanan, Wan, Qin, Qin, Yingfen, Hu, Ruying, Shi, Lixin, Su, Qing, Yu, Xuefeng, Yan, Li, Qin, Guijun, Tang, Xulei, Chen, Gang, Xu, Min, Xu, Yu, Wang, Tiange, Zhao, Zhiyun, Gao, Zhengnan, Wang, Guixia, Shen, Feixia, Luo, Zuojie, Chen, Li, Li, Qiang, Ye, Zhen, Zhang, Yinfei, Liu, Chao, Wang, Youmin, Yang, Tao, Deng, Huacong, Chen, Lulu, Zeng, Tianshu, Li, Donghui, Zhao, Jiajun, Mu, Yiming, Bi, Yufang, Wang, Weiqing, Ning, Guang, Wu, Shengli, Chen, Yuhong, Lu, Jieli
Format: Article
Language:English
Subjects:
Adolescent
Adult
age at diagnosis of diabetes
Age Factors
Body Mass Index
cardiovascular disease
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - pathology
China - epidemiology
Diabetes Mellitus, Type 2 - physiopathology
early-onset diabetes
Endocrinology
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
obesity
Obesity - physiopathology
Prognosis
Risk Factors
type 2 diabetes
Young Adult
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Summary:Nationwide studies focusing on the impact of early-onset type 2 diabetes and obesity on the development of cardiovascular diseases (CVD) are limited in China. We aimed to investigate the association between age at diagnosis of type 2 diabetes and the risk of CVD, and to further examine the modifying effect of obesity on this association among Chinese adults. This study included 23,961 participants with previously diagnosed diabetes from a large nationwide population-based cohort study across mainland China. With an interviewer-assisted questionnaire, we collected detailed information on CVDs. Logistic regression analysis was used to evaluate the risk of CVDs associated with age at diagnosis of diabetes. Compared with patients with late-onset diabetes (≥60 years), those with earlier-onset diabetes had increased risks for CVD, with adjusted ORs (95% CIs) of 1.72 (1.36-2.17), 1.52 (1.31-1.75) and 1.33 (1.19-1.48) for patients diagnosed aged
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.717069