Hepatitis a virus vaccine escape variants and potential new serotype emergence

Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men. The need to complete the proper vaccination schedules is critical, particularly in the immunocompromised population, to prevent the emergence...

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Bibliographic Details
Published in:Emerging infectious diseases 2011-04, Vol.17 (4), p.734-737
Main Authors: Pérez-Sautu, Unai, Costafreda, M Isabel, Caylà, Joan, Tortajada, Cecilia, Lite, Josep, Bosch, Albert, Pintó, Rosa M
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Antigenic Variation - immunology
capsid structural constraints
codon usage
Disease transmission
Dispatch
Health aspects
Hepatitis A
Hepatitis A - classification
Hepatitis A - virology
Hepatitis A vaccine
Hepatitis A Vaccines
Hepatitis A virus
Hepatitis A virus - genetics
Hepatitis A virus - immunology
Humans
Immunocompromised Host - immunology
Male
molecular epidemiology
Mutation - genetics
Phylogeny
Prevention
quasispecies
Vaccination
Viral Structural Proteins - genetics
viruses
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Summary:Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men. The need to complete the proper vaccination schedules is critical, particularly in the immunocompromised population, to prevent the emergence of vaccine-escaping variants.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1704.101169