Association between anti-thyroid peroxidase antibody and asthma in women

About 8% of the general population suffers from autoimmune diseases, from which 78% are women. One of the most important causes of thyroid diseases is autoimmunity in origin, and it seems that people with thyroid diseases present more signs of asthma. This study was therefore designed to investigate...

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Bibliographic Details
Published in:Iranian journal of allergy, asthma, and immunology asthma, and immunology, 2012-09, Vol.11 (3), p.241-245
Main Authors: Samareh Fekri, Mitra, Shokoohi, Mostafa, Gozashti, Mohammad-Hossein, Esmailian, Saeed, Jamshidian, Nasrollah, Shadkam-Farokhi, Malihe, Lashkarizadeh, Mohammad-Reza, Malekpour Afshar, Reza
Format: Article
Language:English
Subjects:
Adult
Anti-thyroid peroxidase antibody
Asthma
Asthma - blood
Asthma - diagnosis
Asthma - epidemiology
Asthma - immunology
Autoantibodies - blood
Autoantigens - immunology
Autoimmune diseases
Body mass index
Case-Control Studies
Chi-Square Distribution
Chronic illnesses
Chronic obstructive pulmonary disease
Cross-Sectional Studies
Female
Hormones
Humans
Hyperthyroidism
Hypothyroidism
Immunoassay
Iodide Peroxidase - immunology
Iran - epidemiology
Iron-Binding Proteins - immunology
Logistic Models
Middle Aged
Multivariate Analysis
Odds Ratio
Older people
Prevalence
Respiratory Function Tests
Statistical analysis
Thyroid diseases
Thyroid function test
Thyroid Function Tests
Thyroiditis, Autoimmune - epidemiology
Thyroiditis, Autoimmune - immunology
Up-Regulation
Women
Womens health
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Summary:About 8% of the general population suffers from autoimmune diseases, from which 78% are women. One of the most important causes of thyroid diseases is autoimmunity in origin, and it seems that people with thyroid diseases present more signs of asthma. This study was therefore designed to investigate the frequency of autoimmune thyroid diseases in women suffering from bronchial asthma.In a cross-sectional study, 100 women with asthma and 100 women as control group were tested for thyroid function and anti-thyroid peroxidase antibody (anti-TPO Ab) measurements. The asthmatic patients were selected based on having chronic cough, dyspnea, wheezing and clinical examination of the chest. The diagnosis was confirmed by pulmonary function tests. Blood tests were done by electrochemiluminescence immunoassay method.No hyperthyroid patient was found in either group. Serum TSH and Total T4 levels were not statistically different between the two groups, but serum anti-TPO Ab levels in women with asthma (74±13.6 IU/ml) was significantly higher than control group (45.24±10.56 IU/ml). After adjusting the effect of age and BMI, the relationship between asthma and anti-TPO Ab (>50 IU/ml) was statistically significant (OR=3.3, P
ISSN:1735-1502
1735-5249