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Possible ameliorating effects of Glycyrrhiza Glabra (Licorice) on the sperm parameters in rats under high fat diet

Adverse effects of obesity, which is caused by an imbalance between the energy intake and expenditure, on the male reproductive system have been reported. Considering the anti-obesity effect of (GC), we conducted this study to elucidate whether it can ameliorate the sperm parameters. In this experim...

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Published in:Endocrine regulations (Bratislava) 2020-01, Vol.54 (1), p.22-30
Main Authors: Ghorbanlou, Mehrdad, Rostamkhani, Somaye, Shokri, Saeed, Mahmazi, Sanaz, Fallah, Ramazan, Moradi, Fateme, Nejatbakhsh, Reza
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container_title Endocrine regulations (Bratislava)
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creator Ghorbanlou, Mehrdad
Rostamkhani, Somaye
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description Adverse effects of obesity, which is caused by an imbalance between the energy intake and expenditure, on the male reproductive system have been reported. Considering the anti-obesity effect of (GC), we conducted this study to elucidate whether it can ameliorate the sperm parameters. In this experimental study, male Wistar rats of 6–8 weeks old were divided into four groups: control, high fat diet (HFD), GC50 (HFD plus 50 mg/kg GC extract), and GC100 (HFD plus 100 mg/kg GC extract). During the 16 weeks of the study course, the rats consumed the extract through gavage, daily. Body mass index (BMI), body weight gain, serum lipid profile, leptin concentration, and sperm parameters were investigated. Data were analyzed by one-way analysis of variance (ANOVA) (post hoc Tukey) to express the significance of mean differences of variables between groups, and linear regression test was used to express the correlation model of variables. Both tests were performed by SPSS software; p≤0.05 was considered significant. BMI was significantly decreased by the GC50 and GC100 groups compared to HFD group. GC50 group considerably decreased leptin level compared to HFD group. A significant positive correlation between leptin and triglyceride levels was evident. GC50 and GC100 extensively increased the total sperm motility and ameliorated the sperm abnormal morphology and count compared to HFD group. extract may exert its ameliorating effects on the sperm parameters through its anti-obesity impact. Both doses of the extract were effective, however, the GC100 was more effective in improving the sperm parameters.
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subjects Animals
Body Mass Index
Diet, High-Fat
Glycyrrhiza
Glycyrrhiza Glabra
high-fat diet
leptin
Leptin - metabolism
Male
Obesity - drug therapy
Obesity - metabolism
Plant Preparations - administration & dosage
Plant Preparations - pharmacology
rat
Rats
Rats, Wistar
sperm
Sperm Count
Sperm Motility - drug effects
Spermatozoa - cytology
Spermatozoa - drug effects
Spermatozoa - pathology
title Possible ameliorating effects of Glycyrrhiza Glabra (Licorice) on the sperm parameters in rats under high fat diet
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