Prognostic Impact of Pattern of Mandibular Involvement in Gingivo-Buccal Complex Squamous Cell Carcinomas: Marrow and Mandibular Canal Staging System

• Published in: Frontiers in oncology 2022-03, Vol.11, p.752018-752018
• Main Authors: Mahajan, Abhishek, Dhone, Navnath, Vaish, Richa, Singhania, Ankita, Malik, Akshat, Prabhash, Kumar, Ahuja, Ankita, Sable, Nilesh, Chaturvedi, Pankaj, Noronha, Vanita, Gosh Laskar, Sarbani, Agarwal, Ujjwal, Shukla, Shreya, Pantvaidya, Gouri, Pai, Prathamesh, Bhattacharjee, Atanu, Patil, Vijay, Patil, Asawari, Bal, Munita, Rane, Swapnil, Thiagarajan, Shivakumar, D' Cruz, Anil
• Format: Article
• Language: English
• Subjects: AJCC 8th edition; gingivo-buccal squamous cell carcinoma; head and neck squamous cell carcinoma; imaging; imaging—computed tomography; Oncology; oral cancer (OC)
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2021.752018

To study the pattern of mandibular involvement and its impact on oncologic outcomes in patients with gingivo-buccal complex squamous cell carcinoma (GBC-SCC) and propose a staging system based on the pattern of bone involvement (MMC: Marrow and mandibular canal staging system) and compare its performance with the 8th edition of the American Joint Committee on Cancer (AJCC8). This retrospective observational study included treatment-naïve GBC-SCC patients who underwent preoperative computed tomography (CT) imaging between January 1, 2012, and March 31, 2016, at a tertiary care cancer center. Patients with T4b disease with high infratemporal fossa involvement, maxillary erosion, and follow-up of less than a year were excluded. The chi-square or Fisher's exact test was used for descriptive analysis. Kaplan-Meier estimate and log-rank test were performed for survival analysis. Multivariate analysis was done using Cox regression analysis after making adjustments for other prognostic factors. p-Value