Time to recurrence after first-ever ischaemic stroke within 3 years and its risk factors in Chinese population: a prospective cohort study

ObjectiveThis study aimed to estimate the time of recurrent ischaemic stroke events among the first 3 years of follow-up after hospitalisation discharge.Study designA prospective cohort study.SettingThe research was conducted in the Department of Neurology at a tertiary hospital, Chengdu of China, f...

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Bibliographic Details
Published in:BMJ open 2019-12, Vol.9 (12), p.e032087-e032087
Main Authors: Zhang, Jing, Zhu, Ping, Liu, Bingqing, Yao, Qiang, Yan, Ke, Zheng, Qianwen, Li, Yawen, Zhang, Lu, Li, Mier, Wang, Ju, Zhu, Cairong, Zhou, Muke
Format: Article
Language:English
Subjects:
Cohort analysis
Epidemiology
Hospitals
Medical records
Patients
Population
Public Health
Quality of life
Questionnaires
Regression analysis
Risk factors
Stroke
Variables
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Summary:ObjectiveThis study aimed to estimate the time of recurrent ischaemic stroke events among the first 3 years of follow-up after hospitalisation discharge.Study designA prospective cohort study.SettingThe research was conducted in the Department of Neurology at a tertiary hospital, Chengdu of China, from January 2010 to June 2016.Outcome measuresWe estimated the restricted mean survival time (RMST) of ischaemic stroke recurrence for the first 3 years after discharge. Basic sociodemographic characteristics and major potential risk factors for recurrence were collected using a semistructured questionnaire. Regression analysis of RMST was used to identify risk factors of recurrent stroke.ParticipantsPatients hospitalised with first-ever ischaemic stroke were eligible for this study. Patients with severe cognitive impairment were excluded.ResultsWe included 641 surviving patients who were followed up for 3 years. Stroke recurrence occurred in 115 patients, including 16 patients who died of stroke recurrence. The cumulative risk of stroke recurrence rate was 11.51% (9.20%–14.35%) at 1 year, 16.76% (13.96%–20.05%) at 2 years and 20.07% (17.00%–23.61%) at 3 years. Modified Rankin Scale (mRS) score ≥3 thus resulted in the recurrence time loss, which was 0.22 months (p=0.008) at 6 months, 0.61 months (p=0.004) at 1 year, 1.49 months (p=0.007) at 2 years and 2.46 months (p=0.008) at 3 years. It is similar with the effects of drug adherence after stroke. The recurrence time of patients ≥75 years at 3 years was 2.02 months (p=0.220) less than that of those aged
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2019-032087