Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation

PVA-sodium alginate (SA) hydrogel membranes containing sodium ampicillin as a topical antibiotic were developed using the freeze–thawing method for wound dressing application. Aqueous solution of sodium alginate has been blended in a certain ratio with PVA, followed by the crosslinking method has be...

Full description

Saved in:
Bibliographic Details
Published in:Arabian journal of chemistry 2015-01, Vol.8 (1), p.38-47
Main Authors: Kamoun, Elbadawy A., Kenawy, El-Refaie S., Tamer, Tamer M., El-Meligy, Mahmoud A., Mohy Eldin, Mohamed S.
Format: Article
Language:English
Subjects:
Alginate
Bio-evaluation
Freeze–thawing method
Hydrogel membranes
Poly(vinyl alcohol)
Wound dressing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PVA-sodium alginate (SA) hydrogel membranes containing sodium ampicillin as a topical antibiotic were developed using the freeze–thawing method for wound dressing application. Aqueous solution of sodium alginate has been blended in a certain ratio with PVA, followed by the crosslinking method has been conducted by freeze–thawing method as physical crosslinking instead of the use of traditional chemical crosslinking to avoid riskiness of chemical reagents and crosslinkers. The physicochemical properties of PVA-SA membranes e.g. gel fraction and water uptake % have been performed. Increased SA content with PVA decreased gel fraction, elasticity, and elongation to break of PVA-SA membranes. However, it resulted in an increase in swelling degree, protein adsorption, and roughness of membrane surface. High SA content in PVA membranes had apparently an impact on surface morphology structure of hydrogel membranes. Pore size and pore area distribution have been observed with addition of high SA concentration. However, high SA content had an insignificant effect on the release of ampicillin. The hydrolytic degradation of PVA-SA membranes has prominently increased with increasing SA content. Furthermore, hemolysis (%) and in vitro inhibition (%) for both Gram positive and negative bacteria have been sharply affected by addition of SA into PVA, indicating the improved blood hemocompatibility. Thus, PVA-SA hydrogel membrane based wound dressing system containing ampicillin could be a good polymeric membrane candidate in wound care.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2013.12.003