An H- TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma

Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule o...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2019-07, Vol.10, p.513
Main Authors: Monti, Eleonora, Dono, Mariella, Gonella, Edoardo, Spina, Bruno, Pitto, Francesca, Petrogalli, Floriana, Conte, Lucia, Ambrosetti, Eleonora, Minuto, Michele N, Ansaldo, Gian Luca, Morbelli, Silvia, Zupo, Simona, Giusti, Massimo
Format: Article
Language:English
Subjects:
Endocrinology
follicular thyroid carcinoma
indeterminate lesions
NRAS
skin metastasis
TERT promoter
THY 3
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Summary:Differentiated thyroid cancer arising from thyroid follicular epithelial cells is the most frequent endocrine malignancy, and skin metastases are very rare. We describe a case of a 70-year-old women with a history of an indeterminate thyroid nodule on cytology. A painless, erythematous skin nodule of about 7 mm diameter was removed from the scalp and diagnosed as a metastasis from thyroid cancer. After total thyroidectomy, a histological diagnosis of follicular thyroid cancer was made. Two cycles of radioactive iodine were performed. Both the follicular thyroid carcinoma (FTC) and the metastasis were investigated for the presence of and promoter mutations. The results showed that the cutaneous metastasis was wild-type and promoter-mutated (position g.1,295,228 C>T); in contrast, the primary thyroid lesion was negative for both molecular markers.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2019.00513