Disability as a determinant of fatigue in MS patients

ABSTRACT Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitt...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2019-04, Vol.77 (4), p.248-253
Main Authors: Taveira, Fernanda M., Braz, Nayara F. T., Comini-Frota, Elizabeth R., Teixeira, Antçnio L., Domingues, Renan B.
Format: Article
Language:English
Subjects:
Adult
Disability Evaluation
Fatigue
Fatigue - complications
Fatigue - physiopathology
Female
Humans
Inflammation
Interleukin-6 - blood
Male
Maximal Respiratory Pressures
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Multivariate Analysis
Muscle Fatigue - physiology
Neurological complications
NEUROSCIENCES
Psychiatric Status Rating Scales
PSYCHIATRY
Quality of Life
Respiration
Respiratory function
Severity of Illness Index
Statistics, Nonparametric
Tumor Necrosis Factor-alpha - blood
Young Adult
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Summary:ABSTRACT Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Central, psychological, and peripheral factors may contribute to the occurrence of fatigue. Objectives: The current study aimed to evaluate potential fatigue determinants in patients with relapsing-remitting MS with a low functional impairment. Methods: We compared inflammatory markers, respiratory pressures, disability, and quality of life in 39 relapsing-remitting MS patients with and without fatigue. Results: Patients with relapsing-remitting MS with fatigue had higher Expanded Disability Status Scale scores (p = 0.002). We observed a significant association between the results of the Guy Neurological Disability Scale, the Functional Assessment of MS Quality of Life Rating Scale and the presence of fatigue (p < 0.05). Conclusions: The degree of functional impairment is a determinant for the presence of fatigue in MS patients, but respiratory function and inflammatory markers are not.
ISSN:0004-282X
1678-4227
1678-4227
DOI:10.1590/0004-282X20190035