The impact of diabetes mellitus on cardiac function assessed by magnetic resonance imaging in patients with hypertrophic cardiomyopathy

The adverse prognostic impact of diabetes on hypertrophic cardiomyopathy (HCM) is poorly understood. We sought to explore the underlying mechanisms in terms of structural and functional remodelling in HCM patients with coexisting diabetes (HCM-DM). A total of 45 HCM-DM patients were retrospectively...

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Bibliographic Details
Published in:Cardiovascular diabetology 2024-08, Vol.23 (1), p.293-9, Article 293
Main Authors: Yu, Shi-Qin, Shi, Ke, Li, Yuan, Wang, Jin, Gao, Yue, Shi, Rui, Yan, Wei-Feng, Xu, Hua-Yan, Guo, Ying-Kun, Yang, Zhi-Gang
Format: Article
Language:English
Subjects:
Adult
Age composition
Aged
Atrial Function, Left
Atrial Remodeling
Cardiac magnetic resonance
Cardiomyopathy
Cardiomyopathy, Hypertrophic - complications
Cardiomyopathy, Hypertrophic - diagnostic imaging
Cardiomyopathy, Hypertrophic - physiopathology
Comorbidity
Diabetes
Diabetes mellitus
Diabetes Mellitus - diagnosis
Diabetes Mellitus - epidemiology
Diabetes Mellitus - physiopathology
Disease
Disease management
Ejection fraction
Female
Fibrosis
Gadolinium
Heart
Humans
Hypertrophic cardiomyopathy
Magnetic resonance imaging
Magnetic Resonance Imaging, Cine
Male
Medical imaging
Middle Aged
Multivariate analysis
Predictive Value of Tests
Prognosis
Retrospective Studies
Risk Factors
Standard deviation
Strain
Stroke Volume
Structure-function relationships
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
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Summary:The adverse prognostic impact of diabetes on hypertrophic cardiomyopathy (HCM) is poorly understood. We sought to explore the underlying mechanisms in terms of structural and functional remodelling in HCM patients with coexisting diabetes (HCM-DM). A total of 45 HCM-DM patients were retrospectively included. Isolated HCM controls (HCM patients without diabetes) were matched to HCM-DM patients in terms of maximal wall thickness, age, and gender distribution. Left ventricular (LV) and atrial (LA) performance were evaluated using cardiac magnetic resonance feature tracking strain analyses. The associations between diabetes and LV/LA impairment were investigated by univariable and multivariable linear regression. Compared with the isolated HCM controls, the HCM-DM patients had smaller end-diastolic volume and stroke volume, lower ejection fraction, larger mass/volume ratio and impaired strains in all three directions (all P 
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-024-02384-y