Evolutionary Aspects of TRPMLs and TPCs

Transient receptor potential (TRP) or transient receptor potential channels are a highly diverse family of mostly non-selective cation channels. In the mammalian genome, 28 members can be identified, most of them being expressed predominantly in the plasma membrane with the exception of the mucolipi...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-06, Vol.21 (11), p.4181
Main Authors: Jaślan, Dawid, Böck, Julia, Krogsaeter, Einar, Grimm, Christian
Format: Article
Language:English
Subjects:
Amino acids
Animals
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Autophagy
Calcium Channels - genetics
Calcium Channels - metabolism
Calcium Channels - physiology
Cations
Defects
endosome
Endosomes
Evolution
Evolution, Molecular
Exocytosis
Fungal Proteins - physiology
Genes
Genomes
Homeostasis
Humans
Insects
Intellectual disabilities
lysosome
Lysosomes
Mammals
Mutation
Phagocytosis
Phylogenetics
Physiology
Plant Proteins - physiology
Review
Signal transduction
TPC1
TPC2
Transient Receptor Potential Channels - genetics
Transient Receptor Potential Channels - metabolism
Transient Receptor Potential Channels - physiology
Transient receptor potential proteins
TRPML1
TRPML2
Zebrafish
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Summary:Transient receptor potential (TRP) or transient receptor potential channels are a highly diverse family of mostly non-selective cation channels. In the mammalian genome, 28 members can be identified, most of them being expressed predominantly in the plasma membrane with the exception of the mucolipins or TRPMLs which are expressed in the endo-lysosomal system. In mammalian organisms, TRPMLs have been associated with a number of critical endo-lysosomal functions such as autophagy, endo-lysosomal fusion/fission and trafficking, lysosomal exocytosis, pH regulation, or lysosomal motility and positioning. The related non-selective two-pore cation channels (TPCs), likewise expressed in endosomes and lysosomes, have also been found to be associated with endo-lysosomal trafficking, autophagy, pH regulation, or lysosomal exocytosis, raising the question why these two channel families have evolved independently. We followed TRP/TRPML channels and TPCs through evolution and describe here in which species TRP/TRPMLs and/or TPCs are found, which functions they have in different species, and how this compares to the functions of mammalian orthologs.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21114181