Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood

Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleukemic somatic mutations, predicts incident cardiovascu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Heart Association 2023-07, Vol.12 (13), p.e030220
Main Authors: Schuermans, Art, Nakao, Tetsushi, Ruan, Yunfeng, Koyama, Satoshi, Yu, Zhi, Uddin, Md Mesbah, Haidermota, Sara, Hornsby, Whitney, Lewandowski, Adam J, Bick, Alexander G, Niroula, Abhishek, Jaiswal, Siddhartha, Ebert, Benjamin L, Natarajan, Pradeep, Honigberg, Michael C
Format: Article
Language:English
Subjects:
Adult
Birth Weight
Cardiac and Cardiovascular Systems
cardiovascular disease
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - genetics
Clinical Medicine
Clonal Hematopoiesis
early life
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
genetics
Health Sciences
Hematopoiesis - genetics
Humans
Hälsovetenskap
Kardiologi
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Mutation
Original Research
Public Health, Global Health, Social Medicine and Epidemiology
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleukemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts development of CHIP later in life is unknown. Methods and Results A total of 221 047 adults enrolled in the UK Biobank with whole exome sequences and self-reported birth weight were analyzed. Of those, 22 030 (11.5%) had low (4.0 kg). CHIP prevalence was higher among participants with low (6.0%, =0.049) and high (6.3%,
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.123.030220