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Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood
Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleukemic somatic mutations, predicts incident cardiovascu...
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| Published in: | Journal of the American Heart Association 2023-07, Vol.12 (13), p.e030220 |
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| creator | Schuermans, Art Nakao, Tetsushi Ruan, Yunfeng Koyama, Satoshi Yu, Zhi Uddin, Md Mesbah Haidermota, Sara Hornsby, Whitney Lewandowski, Adam J Bick, Alexander G Niroula, Abhishek Jaiswal, Siddhartha Ebert, Benjamin L Natarajan, Pradeep Honigberg, Michael C |
| description | Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleukemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts development of CHIP later in life is unknown. Methods and Results A total of 221 047 adults enrolled in the UK Biobank with whole exome sequences and self-reported birth weight were analyzed. Of those, 22 030 (11.5%) had low (4.0 kg). CHIP prevalence was higher among participants with low (6.0%,
=0.049) and high (6.3%, |
| doi_str_mv | 10.1161/JAHA.123.030220 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_0d0b797babec43fb8c439a6fafd33620</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_0d0b797babec43fb8c439a6fafd33620</doaj_id><sourcerecordid>2828759447</sourcerecordid><originalsourceid>FETCH-LOGICAL-c529t-a7e69565ae4c1df8b4def33cc55734ae3087322f0589020da27dfb3c80216e3d3</originalsourceid><addsrcrecordid>eNpVks9vFCEUxydGY5vaszfD0ctu-THMwMmsG3XXbFIPmh4JA49dmplhBabqfy_r1KZL8uCF9-XzgHyr6i3BS0IacvN1tVktCWVLzDCl-EV1SXHdLqQU-OWz_KK6Tukel9HQlnH5urpgLau5oOyy-v3Rx3xAd-D3h4y2Ca1SCsbrDBbd-VJZ92HUPdrAoHM4Bg_JJxQc2o4WMsTBj0WLvoUMY_ZFqEeL1jpaHx50MlOvI7qdsgkDJORHtLJTnw8h2DfVK6f7BNeP61X14_On7-vNYnf7Zbte7RaGU5kXuoVG8oZrqA2xTnS1BceYMZyXN2hgWLSMUoe5kJhiq2lrXceMwJQ0wCy7qrYz1wZ9r47RDzr-UUF79W8jxL3SMXvTg8IWd61sO92BqZnrRJmlbpx2lrGG4sLazaz0C45Td0brp2OJroRKoAxgIy1wVTthVG1EpzqmiaqFcwRLaXBzwn2YcYU1gDXlB6Puz6jnldEf1D48KIIZb7CQhfD-kRDDzwlSVoNPBvpejxCmpKigouWyrtsivZmlJoaUIrinPgSrk53UyU6q2EnNdion3j2_3pP-v3nYX0G2yAE</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2828759447</pqid></control><display><type>article</type><title>Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood</title><source>Open Access: Wiley-Blackwell Open Access Journals</source><source>PubMed Central</source><creator>Schuermans, Art ; Nakao, Tetsushi ; Ruan, Yunfeng ; Koyama, Satoshi ; Yu, Zhi ; Uddin, Md Mesbah ; Haidermota, Sara ; Hornsby, Whitney ; Lewandowski, Adam J ; Bick, Alexander G ; Niroula, Abhishek ; Jaiswal, Siddhartha ; Ebert, Benjamin L ; Natarajan, Pradeep ; Honigberg, Michael C</creator><creatorcontrib>Schuermans, Art ; Nakao, Tetsushi ; Ruan, Yunfeng ; Koyama, Satoshi ; Yu, Zhi ; Uddin, Md Mesbah ; Haidermota, Sara ; Hornsby, Whitney ; Lewandowski, Adam J ; Bick, Alexander G ; Niroula, Abhishek ; Jaiswal, Siddhartha ; Ebert, Benjamin L ; Natarajan, Pradeep ; Honigberg, Michael C</creatorcontrib><description>Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleukemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts development of CHIP later in life is unknown. Methods and Results A total of 221 047 adults enrolled in the UK Biobank with whole exome sequences and self-reported birth weight were analyzed. Of those, 22 030 (11.5%) had low (<2.5 kg) and 29 292 (14.7%) high birth weight (>4.0 kg). CHIP prevalence was higher among participants with low (6.0%,
=0.049) and high (6.3%,
<0.001) versus normal birth weight (5.7%, ref.). Multivariable-adjusted logistic regression analyses demonstrated that each 1-kg increase in birth weight was associated with a 3% increased risk of CHIP (odds ratio, 1.03 [95% CI, 1.00-1.06];
=0.04), driven by a stronger association observed between birth weight and
CHIP (odds ratio, 1.04 per 1-kg increase [95% CI, 1.01-1.08];
=0.02). Mendelian randomization analyses supported a causal relationship of longer gestational age at delivery with
CHIP. Multivariable Cox regression demonstrated that CHIP was independently and additively associated with incident cardiovascular disease or death across birth weight groups, with highest absolute risks in those with CHIP plus high or low birth weight. Conclusions Higher birth weight is associated with increased risk of developing CHIP in midlife, especially
CHIP. These findings identify a novel risk factor for CHIP and provide insights into the relationships among early-life environment, CHIP, cancer, and cardiovascular disease.</description><identifier>ISSN: 2047-9980</identifier><identifier>EISSN: 2047-9980</identifier><identifier>DOI: 10.1161/JAHA.123.030220</identifier><identifier>PMID: 37345823</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Adult ; Birth Weight ; Cardiac and Cardiovascular Systems ; cardiovascular disease ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - genetics ; Clinical Medicine ; Clonal Hematopoiesis ; early life ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; genetics ; Health Sciences ; Hematopoiesis - genetics ; Humans ; Hälsovetenskap ; Kardiologi ; Klinisk medicin ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Mutation ; Original Research ; Public Health, Global Health, Social Medicine and Epidemiology ; Risk Factors</subject><ispartof>Journal of the American Heart Association, 2023-07, Vol.12 (13), p.e030220</ispartof><rights>2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-a7e69565ae4c1df8b4def33cc55734ae3087322f0589020da27dfb3c80216e3d3</citedby><cites>FETCH-LOGICAL-c529t-a7e69565ae4c1df8b4def33cc55734ae3087322f0589020da27dfb3c80216e3d3</cites><orcidid>0000-0003-0197-5451 ; 0000-0003-4810-3474 ; 0000-0001-8630-5021 ; 0000-0001-5824-9595 ; 0000-0001-8402-7435 ; 0000-0002-9597-0477 ; 0000-0002-3213-8309 ; 0000-0003-1846-0411 ; 0000-0002-4978-8965 ; 0000-0001-8146-9692 ; 0000-0002-9286-0360 ; 0000-0002-5904-0635</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356089/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356089/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37345823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/ce0c9de5-4f8c-4c8b-b3a1-48ff1099c060$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Schuermans, Art</creatorcontrib><creatorcontrib>Nakao, Tetsushi</creatorcontrib><creatorcontrib>Ruan, Yunfeng</creatorcontrib><creatorcontrib>Koyama, Satoshi</creatorcontrib><creatorcontrib>Yu, Zhi</creatorcontrib><creatorcontrib>Uddin, Md Mesbah</creatorcontrib><creatorcontrib>Haidermota, Sara</creatorcontrib><creatorcontrib>Hornsby, Whitney</creatorcontrib><creatorcontrib>Lewandowski, Adam J</creatorcontrib><creatorcontrib>Bick, Alexander G</creatorcontrib><creatorcontrib>Niroula, Abhishek</creatorcontrib><creatorcontrib>Jaiswal, Siddhartha</creatorcontrib><creatorcontrib>Ebert, Benjamin L</creatorcontrib><creatorcontrib>Natarajan, Pradeep</creatorcontrib><creatorcontrib>Honigberg, Michael C</creatorcontrib><title>Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood</title><title>Journal of the American Heart Association</title><addtitle>J Am Heart Assoc</addtitle><description>Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleukemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts development of CHIP later in life is unknown. Methods and Results A total of 221 047 adults enrolled in the UK Biobank with whole exome sequences and self-reported birth weight were analyzed. Of those, 22 030 (11.5%) had low (<2.5 kg) and 29 292 (14.7%) high birth weight (>4.0 kg). CHIP prevalence was higher among participants with low (6.0%,
=0.049) and high (6.3%,
<0.001) versus normal birth weight (5.7%, ref.). Multivariable-adjusted logistic regression analyses demonstrated that each 1-kg increase in birth weight was associated with a 3% increased risk of CHIP (odds ratio, 1.03 [95% CI, 1.00-1.06];
=0.04), driven by a stronger association observed between birth weight and
CHIP (odds ratio, 1.04 per 1-kg increase [95% CI, 1.01-1.08];
=0.02). Mendelian randomization analyses supported a causal relationship of longer gestational age at delivery with
CHIP. Multivariable Cox regression demonstrated that CHIP was independently and additively associated with incident cardiovascular disease or death across birth weight groups, with highest absolute risks in those with CHIP plus high or low birth weight. Conclusions Higher birth weight is associated with increased risk of developing CHIP in midlife, especially
CHIP. These findings identify a novel risk factor for CHIP and provide insights into the relationships among early-life environment, CHIP, cancer, and cardiovascular disease.</description><subject>Adult</subject><subject>Birth Weight</subject><subject>Cardiac and Cardiovascular Systems</subject><subject>cardiovascular disease</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Clinical Medicine</subject><subject>Clonal Hematopoiesis</subject><subject>early life</subject><subject>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</subject><subject>genetics</subject><subject>Health Sciences</subject><subject>Hematopoiesis - genetics</subject><subject>Humans</subject><subject>Hälsovetenskap</subject><subject>Kardiologi</subject><subject>Klinisk medicin</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Mutation</subject><subject>Original Research</subject><subject>Public Health, Global Health, Social Medicine and Epidemiology</subject><subject>Risk Factors</subject><issn>2047-9980</issn><issn>2047-9980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVks9vFCEUxydGY5vaszfD0ctu-THMwMmsG3XXbFIPmh4JA49dmplhBabqfy_r1KZL8uCF9-XzgHyr6i3BS0IacvN1tVktCWVLzDCl-EV1SXHdLqQU-OWz_KK6Tukel9HQlnH5urpgLau5oOyy-v3Rx3xAd-D3h4y2Ca1SCsbrDBbd-VJZ92HUPdrAoHM4Bg_JJxQc2o4WMsTBj0WLvoUMY_ZFqEeL1jpaHx50MlOvI7qdsgkDJORHtLJTnw8h2DfVK6f7BNeP61X14_On7-vNYnf7Zbte7RaGU5kXuoVG8oZrqA2xTnS1BceYMZyXN2hgWLSMUoe5kJhiq2lrXceMwJQ0wCy7qrYz1wZ9r47RDzr-UUF79W8jxL3SMXvTg8IWd61sO92BqZnrRJmlbpx2lrGG4sLazaz0C45Td0brp2OJroRKoAxgIy1wVTthVG1EpzqmiaqFcwRLaXBzwn2YcYU1gDXlB6Puz6jnldEf1D48KIIZb7CQhfD-kRDDzwlSVoNPBvpejxCmpKigouWyrtsivZmlJoaUIrinPgSrk53UyU6q2EnNdion3j2_3pP-v3nYX0G2yAE</recordid><startdate>20230704</startdate><enddate>20230704</enddate><creator>Schuermans, Art</creator><creator>Nakao, Tetsushi</creator><creator>Ruan, Yunfeng</creator><creator>Koyama, Satoshi</creator><creator>Yu, Zhi</creator><creator>Uddin, Md Mesbah</creator><creator>Haidermota, Sara</creator><creator>Hornsby, Whitney</creator><creator>Lewandowski, Adam J</creator><creator>Bick, Alexander G</creator><creator>Niroula, Abhishek</creator><creator>Jaiswal, Siddhartha</creator><creator>Ebert, Benjamin L</creator><creator>Natarajan, Pradeep</creator><creator>Honigberg, Michael C</creator><general>John Wiley and Sons Inc</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0197-5451</orcidid><orcidid>https://orcid.org/0000-0003-4810-3474</orcidid><orcidid>https://orcid.org/0000-0001-8630-5021</orcidid><orcidid>https://orcid.org/0000-0001-5824-9595</orcidid><orcidid>https://orcid.org/0000-0001-8402-7435</orcidid><orcidid>https://orcid.org/0000-0002-9597-0477</orcidid><orcidid>https://orcid.org/0000-0002-3213-8309</orcidid><orcidid>https://orcid.org/0000-0003-1846-0411</orcidid><orcidid>https://orcid.org/0000-0002-4978-8965</orcidid><orcidid>https://orcid.org/0000-0001-8146-9692</orcidid><orcidid>https://orcid.org/0000-0002-9286-0360</orcidid><orcidid>https://orcid.org/0000-0002-5904-0635</orcidid></search><sort><creationdate>20230704</creationdate><title>Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood</title><author>Schuermans, Art ; Nakao, Tetsushi ; Ruan, Yunfeng ; Koyama, Satoshi ; Yu, Zhi ; Uddin, Md Mesbah ; Haidermota, Sara ; Hornsby, Whitney ; Lewandowski, Adam J ; Bick, Alexander G ; Niroula, Abhishek ; Jaiswal, Siddhartha ; Ebert, Benjamin L ; Natarajan, Pradeep ; Honigberg, Michael C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-a7e69565ae4c1df8b4def33cc55734ae3087322f0589020da27dfb3c80216e3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Birth Weight</topic><topic>Cardiac and Cardiovascular Systems</topic><topic>cardiovascular disease</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Clinical Medicine</topic><topic>Clonal Hematopoiesis</topic><topic>early life</topic><topic>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</topic><topic>genetics</topic><topic>Health Sciences</topic><topic>Hematopoiesis - genetics</topic><topic>Humans</topic><topic>Hälsovetenskap</topic><topic>Kardiologi</topic><topic>Klinisk medicin</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Mutation</topic><topic>Original Research</topic><topic>Public Health, Global Health, Social Medicine and Epidemiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schuermans, Art</creatorcontrib><creatorcontrib>Nakao, Tetsushi</creatorcontrib><creatorcontrib>Ruan, Yunfeng</creatorcontrib><creatorcontrib>Koyama, Satoshi</creatorcontrib><creatorcontrib>Yu, Zhi</creatorcontrib><creatorcontrib>Uddin, Md Mesbah</creatorcontrib><creatorcontrib>Haidermota, Sara</creatorcontrib><creatorcontrib>Hornsby, Whitney</creatorcontrib><creatorcontrib>Lewandowski, Adam J</creatorcontrib><creatorcontrib>Bick, Alexander G</creatorcontrib><creatorcontrib>Niroula, Abhishek</creatorcontrib><creatorcontrib>Jaiswal, Siddhartha</creatorcontrib><creatorcontrib>Ebert, Benjamin L</creatorcontrib><creatorcontrib>Natarajan, Pradeep</creatorcontrib><creatorcontrib>Honigberg, Michael C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><collection>Directory of Open Access Journals</collection><jtitle>Journal of the American Heart Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schuermans, Art</au><au>Nakao, Tetsushi</au><au>Ruan, Yunfeng</au><au>Koyama, Satoshi</au><au>Yu, Zhi</au><au>Uddin, Md Mesbah</au><au>Haidermota, Sara</au><au>Hornsby, Whitney</au><au>Lewandowski, Adam J</au><au>Bick, Alexander G</au><au>Niroula, Abhishek</au><au>Jaiswal, Siddhartha</au><au>Ebert, Benjamin L</au><au>Natarajan, Pradeep</au><au>Honigberg, Michael C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood</atitle><jtitle>Journal of the American Heart Association</jtitle><addtitle>J Am Heart Assoc</addtitle><date>2023-07-04</date><risdate>2023</risdate><volume>12</volume><issue>13</issue><spage>e030220</spage><pages>e030220-</pages><issn>2047-9980</issn><eissn>2047-9980</eissn><abstract>Background High and low birth weight are independently associated with increased cardiovascular disease risk in adulthood. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related clonal expansion of hematopoietic cells with preleukemic somatic mutations, predicts incident cardiovascular disease independent of traditional cardiovascular risk factors. Whether birth weight predicts development of CHIP later in life is unknown. Methods and Results A total of 221 047 adults enrolled in the UK Biobank with whole exome sequences and self-reported birth weight were analyzed. Of those, 22 030 (11.5%) had low (<2.5 kg) and 29 292 (14.7%) high birth weight (>4.0 kg). CHIP prevalence was higher among participants with low (6.0%,
=0.049) and high (6.3%,
<0.001) versus normal birth weight (5.7%, ref.). Multivariable-adjusted logistic regression analyses demonstrated that each 1-kg increase in birth weight was associated with a 3% increased risk of CHIP (odds ratio, 1.03 [95% CI, 1.00-1.06];
=0.04), driven by a stronger association observed between birth weight and
CHIP (odds ratio, 1.04 per 1-kg increase [95% CI, 1.01-1.08];
=0.02). Mendelian randomization analyses supported a causal relationship of longer gestational age at delivery with
CHIP. Multivariable Cox regression demonstrated that CHIP was independently and additively associated with incident cardiovascular disease or death across birth weight groups, with highest absolute risks in those with CHIP plus high or low birth weight. Conclusions Higher birth weight is associated with increased risk of developing CHIP in midlife, especially
CHIP. These findings identify a novel risk factor for CHIP and provide insights into the relationships among early-life environment, CHIP, cancer, and cardiovascular disease.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>37345823</pmid><doi>10.1161/JAHA.123.030220</doi><orcidid>https://orcid.org/0000-0003-0197-5451</orcidid><orcidid>https://orcid.org/0000-0003-4810-3474</orcidid><orcidid>https://orcid.org/0000-0001-8630-5021</orcidid><orcidid>https://orcid.org/0000-0001-5824-9595</orcidid><orcidid>https://orcid.org/0000-0001-8402-7435</orcidid><orcidid>https://orcid.org/0000-0002-9597-0477</orcidid><orcidid>https://orcid.org/0000-0002-3213-8309</orcidid><orcidid>https://orcid.org/0000-0003-1846-0411</orcidid><orcidid>https://orcid.org/0000-0002-4978-8965</orcidid><orcidid>https://orcid.org/0000-0001-8146-9692</orcidid><orcidid>https://orcid.org/0000-0002-9286-0360</orcidid><orcidid>https://orcid.org/0000-0002-5904-0635</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Open Access: Wiley-Blackwell Open Access Journals; PubMed Central |
| subjects | Adult Birth Weight Cardiac and Cardiovascular Systems cardiovascular disease Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Clinical Medicine Clonal Hematopoiesis early life Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi genetics Health Sciences Hematopoiesis - genetics Humans Hälsovetenskap Kardiologi Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap Mutation Original Research Public Health, Global Health, Social Medicine and Epidemiology Risk Factors |
| title | Birth Weight Is Associated With Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Adulthood |
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