Immune System Modulation and Viral Persistence in Bats: Understanding Viral Spillover

Bats harbor a myriad of viruses and some of these viruses may have spilled over to other species including humans. Spillover events are rare and several factors must align to create the "perfect storm" that would ultimately lead to a spillover. One of these factors is the increased sheddin...

Full description

Saved in:
Bibliographic Details
Published in:Viruses 2019-02, Vol.11 (2), p.192
Main Authors: Subudhi, Sonu, Rapin, Noreen, Misra, Vikram
Format: Article
Language:English
Subjects:
Animals
Bats
Chiroptera
Chiroptera - immunology
Chiroptera - virology
Disease Reservoirs - virology
flight
Immune response
Immune system
Immune Tolerance
Interferon
Latent infection
Molecular modelling
Review
spillover
Viral infections
Viral Load
viral persistence
Virus Latency - immunology
Virus Replication
Virus Shedding
Viruses
Viruses - immunology
Viruses - pathogenicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bats harbor a myriad of viruses and some of these viruses may have spilled over to other species including humans. Spillover events are rare and several factors must align to create the "perfect storm" that would ultimately lead to a spillover. One of these factors is the increased shedding of virus by bats. Several studies have indicated that bats have unique defense mechanisms that allow them to be persistently or latently infected with viruses. Factors leading to an increase in the viral load of persistently infected bats would facilitate shedding of virus. This article reviews the unique nature of bat immune defenses that regulate virus replication and the various molecular mechanisms that play a role in altering the balanced bat⁻virus relationship.
ISSN:1999-4915
1999-4915
DOI:10.3390/v11020192