The pro-inflammatory and anti-inflammatory role of hyaluronic acid in endometriosis

Endometriosis is a bothersome disease affected women worldwide, the mechanism of disease development is still under investigation. Several inflammatory responses after clinical hyaluronic acid (HA) use were reported. Cyclooxygenase (COX)-2 mediated inflammation pathway is involved in the pathogenesi...

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Published in:Taiwanese journal of obstetrics & gynecology 2021-07, Vol.60 (4), p.711-717
Main Authors: Yu, Pei-Hsiu, Chou, Pei-Yi, Li, Wan-Ning, Tsai, Shaw-Jenq, Wu, Meng-Hsing
Format: Article
Language:English
Subjects:
Cyclooxygenase-2
Endometriosis
hyaluronic acid
Inflammation
Interleukin-1 beta
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Summary:Endometriosis is a bothersome disease affected women worldwide, the mechanism of disease development is still under investigation. Several inflammatory responses after clinical hyaluronic acid (HA) use were reported. Cyclooxygenase (COX)-2 mediated inflammation pathway is involved in the pathogenesis of endometriosis. Thus, we tried to investigate the inflammatory role of hyaluronic acid in endometriosis. Peritoneal fluid was collected in endometriosis and disease-free patients for the measurement of HA. Endometriotic stromal cells were treated with IL-1β and HA and expression of COX-2 was evaluated. Mice model of endometriosis was established and treated with fluid or gel form of HA. Endometriotic lesion size and weight were recorded and level of COX-2 was evaluated by immunohistochemistry staining. The level of HA in the peritoneal fluid had no statistically significant difference between normal, early and advanced stage endometriosis patients. The overexpression of COX-2 protein was detected when treating endometriotic stromal cell with HA in the presence of IL-1β (P 
ISSN:1028-4559
DOI:10.1016/j.tjog.2021.05.022