Hematological and Biochemical Characteristics Associated with Cytogenetic Findern Alterations in Adult Patients with Acute Lymphoblastic Leukemia from the Northern Region of Brazil

Acute lymphoblastic leukemia (ALL) is an aggressive neoplasm derived from B and/or T cell lineage (B-ALL; T-ALL). For the first time, this study describes, cytogenetically, the karyotypic alterations in adults with ALL in the northern region of Brazil and their relationship with hematological and bi...

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Published in:Biomedicines 2024-12, Vol.12 (12), p.2739
Main Authors: Duarte, Dejair da Silva, Teixeira, Eliel Barbosa, de Oliveira, Marcelo Braga, Carneiro, Thiago Xavier, Leão, Lucyana Barbosa Cardoso, Mello Júnior, Fernando Augusto Rodrigues, Carneiro, Debora Monteiro, Nunes, Patricia Ferreira, Cohen-Paes, Amanda, Alcantara, Diego Di Felipe Ávila, Khayat, André Salim, Burbano, Rommel Mario Rodriguez
Format: Article
Language:English
Subjects:
22
Acute lymphoblastic leukemia
Acute lymphocytic leukemia
Adults
Aneuploidy
Biochemical characteristics
Blood levels
Cell lineage
Chemotherapy
Chromosome 21
chromosome 21 aneuploidy
Chromosome translocations
Chromosomes
Cytogenetics
Erythrocytes
hematological characteristics
Hematology
Hemoglobin
Kinases
Leukemia
Lymphocytes T
Medical prognosis
Medical records
Medical research
Medicine, Experimental
Prognosis
T cells
Urea
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Summary:Acute lymphoblastic leukemia (ALL) is an aggressive neoplasm derived from B and/or T cell lineage (B-ALL; T-ALL). For the first time, this study describes, cytogenetically, the karyotypic alterations in adults with ALL in the northern region of Brazil and their relationship with hematological and biochemical characteristics. Through banding analyses, immunophenotyping, as well as hematological and biochemical examination data obtained directly from patients’ records, we found that chromosome 21 aneuploidy was the most frequent. The cytogenetic structural alterations observed with the highest incidence among the patients were: t(9;22), t(4;11), t(1;19), del(6q), and del(9p). In patients presenting with chromosome alterations, we verified that patients with t(4;11) have elevated red blood cell levels and patients with del(9p) presented with distinct and high values of hematological parameters compared to other patients. Regarding biochemical alterations, we observed that patients with translocations (4;11) and del(6q) presented with elevated urea levels compared to other patients, highlighting its relationship to kidney changes and patient prognosis. Thus, our study highlights that variations in hematological and biochemical data are associated with specific cytogenetic changes and other factors, which may impact the prognosis of adult patients with ALL.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12122739