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Respiratory Aspergillus Colonization Was Associated With Relapse of Acute Exacerbation in Patients With Chronic Obstructive Pulmonary Disease: Analysis of Data From A Retrospective Cohort Study
Patients with chronic obstructive pulmonary disease (COPD) are more susceptible to colonization or infection. Several studies have demonstrated that invasive pulmonary Aspergillosis (IPA) and hypersensitivity (AH) have a detrimental effect on COPD. However, it remains to be clarified whether coloniz...
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Published in: | Frontiers in medicine 2021-05, Vol.8, p.640289-640289 |
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Main Authors: | , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Patients with chronic obstructive pulmonary disease (COPD) are more susceptible to
colonization or infection. Several studies have demonstrated that invasive pulmonary Aspergillosis (IPA) and
hypersensitivity (AH) have a detrimental effect on COPD. However, it remains to be clarified whether
colonization is associated with acute exacerbation of COPD (AECOPD). This study aimed to explore the impact of
colonization in the lower respiratory tract on AECOPD.
Patients with
colonization were identified from a retrospective cohort of hospitalized AECOPD from 2011 to 2016 in eight centers in Shanghai, China. The demographic information, conditions of the stable stage, clinical characteristics during hospitalization, and 1-year follow-up information after discharge were collected and compared to participants without fungi colonization.
Twenty-six hospitalized AECOPD patients with
colonization and 72 controls were included in the final analysis after excluding patients with other fungi isolation and matching. The rates of recurrence of acute exacerbation within 90 days and 180 days after discharge in the patients with
colonization were both significantly higher than that in the fungi negative patients (90 days: 19.2 vs. 4.2%,
= 0.029; 180 days: 23.1 vs. 4.2%,
= 0.010), and the all-cause mortality within 1 year was also higher (11.5 vs. 0.0%,
= 0.017). Multivariate logistic regression analysis showed that
colonization was an independent risk factor for the recurrence of acute exacerbation within 90 days and 180 days (90 days: OR = 8.661, 95% CI: 1.496-50.159,
= 0.016; 180 days: OR =10.723, 95% CI: 1.936-59.394,
= 0.007).
colonization may predict poor prognosis of AECOPD while leading to an increased risk of recurrent AECOPD in a short period. |
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ISSN: | 2296-858X 2296-858X |
DOI: | 10.3389/fmed.2021.640289 |