Investigation of immunovascular polymorphisms and intersections in psoriasis

Background: Psoriasis is a chronic, inflammatory skin disease. The etiology of the disease is unknown. It is a polygenic and multifactorial disease, which interacts with genetic and environmental factors. Genetic factors (polymorphism/mutation) can alter the immune system and normal physiologically...

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Bibliographic Details
Published in:Indian journal of dermatology 2019-05, Vol.64 (3), p.187-191
Main Authors: Urganci, Buket, Acikbas, Ibrahim, Er, F
Format: Article
Language:English
Subjects:
5HT2A
Age
Angiogenesis
Basic Research
Deoxyribonucleic acid
Development and progression
Disease
DNA
EDTA
Endothelial growth factors
Endothelium
Etiology (Medicine)
Family medical history
Genetic aspects
Genetic polymorphisms
Haplotypes
HIF-1α
IL-10
Immune system
Investigations
Novels
Patients
Polymorphism
Psoriasis
Skin
Skin diseases
Thermal cycling
TNF-α
Vascular endothelial growth factor
VEGF
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Summary:Background: Psoriasis is a chronic, inflammatory skin disease. The etiology of the disease is unknown. It is a polygenic and multifactorial disease, which interacts with genetic and environmental factors. Genetic factors (polymorphism/mutation) can alter the immune system and normal physiologically functioning keratinocytes to pathological or predisposition levels. Aims: We aimed to investigate psoriasis at a different and novel window by searching for vascular and immunological variations and intersections in psoriasis. We investigated the main vascular and hypoxic controlling factors, which are vascular endothelial growth factor (VEGF) and hypoxia inducible factor 1 alpha (HIF-1α), as well as immunological and serotonergic factors, such as TNF-α, IL-10, and 5HT2A, which could connect each other to the pathogenesis of psoriasis. Subjects and Methods: Nine single nucleotide polymorphisms (SNPs) in five genes were genotyped by mini-array format in 300 subjects: VEGF (rs2010963, rs833061, and rs1570360), HIF-1α (rs11549465), TNF-α (rs361525, rs1799964, and rs1800629), IL-10 (rs1800896), and 5HT2A (rs6311). Results: An association was found between rs1800629 (TNF-α) and Type I psoriasis, and rs833061 (VEGF) and Type II psoriasis. Haplotype analysis suggests that the coexistence of the polymorphisms rs1799964 (TNF-α), rs2010963 (VEGF), rs833061 (VEGF), and rs6311 (5HT2A) may be a protective factor for psoriasis. Conclusion: Our results suggest that the vascular component of the studied vasculo-immunologic variation is more relevant in the pathogenesis of psoriasis.
ISSN:0019-5154
1998-3611
DOI:10.4103/ijd.IJD_422_18