Thermodynamic Analysis of the Solubility of Isoniazid in (PEG 200 + Water) Cosolvent Mixtures from 278.15 K to 318.15 K

The solubility of drugs in cosolvent systems of pharmaceutical interest is of great importance for understanding and optimizing a large number of processes. Here, we report the solubility of isoniazid in nine (PEG 200 + water) cosolvent mixtures at nine temperatures (278.15, 283.15, 288.15, 293.15,...

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Published in:International journal of molecular sciences 2022-09, Vol.23 (17), p.10190
Main Authors: Baracaldo-Santamaría, Daniela, Calderon-Ospina, Carlos Alberto, Ortiz, Claudia Patricia, Cardenas-Torres, Rossember Edén, Martinez, Fleming, Delgado, Daniel Ricardo
Format: Article
Language:English
Subjects:
cosolvent
Endothermic reactions
Entropy of solution
Ethanol
Isoniazid
Mixtures
PEG 200
Pharmaceuticals
Polyethylene glycol
Solubility
Solvents
Spectrophotometry
Temperature
Thermodynamics
Transfer functions
Tuberculosis
water
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Summary:The solubility of drugs in cosolvent systems of pharmaceutical interest is of great importance for understanding and optimizing a large number of processes. Here, we report the solubility of isoniazid in nine (PEG 200 + water) cosolvent mixtures at nine temperatures (278.15, 283.15, 288.15, 293.15, 298.15, 303.15, 308.15, and 318.15 K) determined by UV–vis spectrophotometry. From the solubility data, the thermodynamic solution, mixing, and transfer functions were calculated in addition to performing the enthalpy–entropy compensation analysis. The solubility of isoniazid depends on the concentration of PEG 200 (positive cosolvent effect) and temperature (endothermic process) reaching its maximum solubility in pure PEG 200 at 318.15 K and the lowest solubility in pure water at 278.15 K. The solution process is favored by the solution entropy and according to the enthalpy–entropy compensation analysis it is driven by entropy in mixtures rich in water and by enthalpy in mixtures rich in PEG 200.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231710190