Use of Oxidative Coupling Strategy as a Means to Increase In Vitro Antioxidant Activity of Vanillin Derivatives

The aim of this study was to investigate the antioxidant properties in vitro of three different vanillic dimmers (Compounds 1a–c). They were synthesized through an oxidative coupling strategy in good yields. The targeted compounds were found to be highly active for the total antioxidant assay, as we...

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Bibliographic Details
Published in:Chemistry Proceedings 2022-11, Vol.12 (1), p.31
Main Authors: Leandro G. Gutierrez, Ana P. Reinick, Carla M. Ormachea, Vanina A. Guntero, Cristián A. Ferretti
Format: Article
Language:English
Subjects:
antioxidant activity
oxidative coupling
vanillic dimers
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Summary:The aim of this study was to investigate the antioxidant properties in vitro of three different vanillic dimmers (Compounds 1a–c). They were synthesized through an oxidative coupling strategy in good yields. The targeted compounds were found to be highly active for the total antioxidant assay, as well as for the lipid peroxidation test. All investigated compounds exhibited superior or comparable antioxidant capacity in comparison to precursor vanillin, proving that oxidative coupling is a great strategy to increase the antioxidant behavior of vanillin derivatives.
ISSN:2673-4583
DOI:10.3390/ecsoc-26-13553