The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases

Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for normal cell functioning, whereas kinase dysregulation o...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-11, Vol.21 (22), p.8824
Main Authors: Obsilova, Veronika, Obsil, Tomas
Format: Article
Language:English
Subjects:
14-3-3
14-3-3 protein
14-3-3 Proteins - genetics
Allosteric properties
Allosteric Regulation - genetics
Apoptosis
Apoptosis - genetics
ASK1
Binding sites
CaMKK2
Cell cycle
Cell differentiation
Disease
Humans
kinase
Kinases
p38 Mitogen-Activated Protein Kinases - genetics
Phosphorylation
Phosphorylation - genetics
Protein interaction
Protein kinase
Protein Kinases - genetics
Proteins
RAF kinase
Regulation
Regulators
Review
Scaffolding
Signal Transduction - genetics
Structure-function relationships
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Summary:Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for normal cell functioning, whereas kinase dysregulation often leads to disease. Moreover, the functions of many kinases are regulated through protein-protein interactions, which in turn are mediated by phosphorylated motifs and often involve associations with the scaffolding and chaperon protein 14-3-3. Therefore, the aim of this review article is to provide an overview of the state of the art on 14-3-3-mediated kinase regulation, focusing on the most recent mechanistic insights into these important protein-protein interactions and discussing in detail both their structural aspects and functional consequences.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21228824