Severe digestive pathology associated with chronic Chagas' disease in Ecuador: report of two cases

DNA extracted from peripheral blood of two Ecuadorian patients showing severe digestive pathology was amplified by the polymerase chain reaction using a Trypanosoma cruzi specific oligonucleotide primers derived from the primary sequence of a cDNA encoding for a 24 kDa excretory/secretory protein. T...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 1997-10, Vol.30 (5), p.389-392
Main Authors: Guevara, A G, Eras, J W, Recalde, M, Vinueza, L, Cooper, P J, Ouaissi, A, Guderian, R H
Format: Article
Language:English
Subjects:
Aged
Animals
Antibodies, Protozoan - blood
Chagas Disease - complications
Chagas Disease - diagnosis
Chagas' disease
Chronic Disease
Digestive System Diseases - diagnosis
Digestive System Diseases - etiology
DNA, Protozoan - blood
Doença de Chagas
Ecuador
Female
Humans
Male
Megacolon
Megacólon
Megaesophagus
Megaesôfago
Middle Aged
Pathology
PCR
Polymerase Chain Reaction
T. cruzi
TROPICAL MEDICINE
Trypanosoma cruzi - genetics
Trypanosoma cruzi - immunology
Vector-borne diseases
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Summary:DNA extracted from peripheral blood of two Ecuadorian patients showing severe digestive pathology was amplified by the polymerase chain reaction using a Trypanosoma cruzi specific oligonucleotide primers derived from the primary sequence of a cDNA encoding for a 24 kDa excretory/secretory protein. The positive PCR results together with the clinical findings confirmed that both patients had a digestive pathology due to Chagas' disease. This pathology could be more frequent than previously described in the chagasic endemic regions of Andean countries.
ISSN:0037-8682
1678-9849
0037-8682
1678-9849
DOI:10.1590/S0037-86821997000500007