Aberrant IL-17 Levels in Rodent Models of Autism Spectrum Disorder: A Systematic Review

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A or IL-17), have been implicated as part of immu...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2022-06, Vol.13, p.874064-874064
Main Authors: Thawley, Alexandra Jade, Veneziani, Luciana Peixoto, Rabelo-da-Ponte, Francisco Diego, Riederer, Ingo, Mendes-da-Cruz, Daniella Areas, Bambini-Junior, Victorio
Format: Article
Language:English
Subjects:
animal model
autism spectrum disorder
IL-17
Immunology
inflammation
systematic review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder characterised by stereotyped behaviours, specific interests, and impaired communication skills. Elevated levels of pro-inflammatory cytokines, such as interleukin-17A (IL-17A or IL-17), have been implicated as part of immune alterations that may contribute to this outcome. In this context, rodent models have helped elucidate the role of T-cell activation and IL-17 secretion in the pathogenesis of ASD. Regarding the preclinical findings, the data available is contradictory in offspring but not in the pregnant dams, pointing to IL-17 as one of the main drivers of altered behaviour in some models ASD, whilst there are no alterations described in IL-17 levels in others. To address this gap in the literature, a systematic review of altered IL-17 levels in rodent models of ASD was conducted. In total, 28 studies that explored IL-17 levels were included and observed that this cytokine was generally increased among the different models of ASD. The data compiled in this review can help the choice of animal models to study the role of cytokines in the development of ASD, seeking a parallel with immune alterations observed in individuals with this condition.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.874064