Hemodynamics during the 10-minute NASA Lean Test: evidence of circulatory decompensation in a subset of ME/CFS patients

Lightheadedness, fatigue, weakness, heart palpitations, cognitive dysfunction, muscle pain, and exercise intolerance are some of the symptoms of orthostatic intolerance (OI). There is substantial comorbidity of OI in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome). The 10-minute NASA Lea...

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Bibliographic Details
Published in:Journal of translational medicine 2020-08, Vol.18 (1), p.314-9, Article 314
Main Authors: Lee, Jihyun, Vernon, Suzanne D, Jeys, Patricia, Ali, Weam, Campos, Andrea, Unutmaz, Derya, Yellman, Brayden, Bateman, Lucinda
Format: Article
Language:English
Subjects:
10-minute NASA lean test
Age
Analysis
Blood pressure
Blood pressure measurement
Care and treatment
Chronic fatigue syndrome
Circulatory decompensation
Cognitive ability
Comorbidity
Diagnosis
Fatigue
Fatigue Syndrome, Chronic
Fibromyalgia
Gender
Heart diseases
Heart Rate
Hemodynamics
Humans
Intolerance
ME/CFS
Orthostatic hypotension
Orthostatic Intolerance
Point-of-care
Questionnaires
Regression analysis
Sleep
Somatotropin
United States
United States National Aeronautics and Space Administration
Venous pressure
Ventricle
Vital signs
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Summary:Lightheadedness, fatigue, weakness, heart palpitations, cognitive dysfunction, muscle pain, and exercise intolerance are some of the symptoms of orthostatic intolerance (OI). There is substantial comorbidity of OI in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome). The 10-minute NASA Lean Test (NLT) is a simple, point-of-care method that can aid ME/CFS diagnosis and guide management and treatment of OI. The objective of this study was to understand the hemodynamic changes that occur in ME/CFS patients during the 10-minute NLT. A total of 150 ME/CFS patients and 75 age, gender and race matched healthy controls (HCs) were enrolled. We recruited 75 ME/CFS patients who had been sick for less than 4 years ( 10 ME/CFS). The 10-minute NLT involves measurement of blood pressure and heart rate while resting supine and every minute for 10 min while standing with shoulder-blades on the wall for a relaxed stance. Spontaneously reported symptoms are recorded during the test. ANOVA and regression analysis were used to test for differences and relationships in hemodynamics, symptoms and upright activity between groups. At least 5 min of the 10-minute NLT were required to detect hemodynamic changes. The  10 ME/CFS and HCs. The  10 ME/CFS and HCs. The circulatory decompensation observed in the 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-020-02481-y