Loneliness, immunological recovery patterns, and health-related quality of life (HRQOL) outcomes in patients receiving hematopoietic stem cell transplantation

Loneliness may compromise health-related quality of life (HRQOL) outcomes and the immunological impacts of loneliness via neuroendocrinological mechanisms likely have consequences for patients who have undergone a hematopoietic stem cell transplantation (HSCT). Loneliness (pre-transplant), immunolog...

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Bibliographic Details
Published in:BMC Psychology 2024-01, Vol.12 (1), p.40-40, Article 40
Main Authors: Lange, Lori J, Ames, Steven C, Ames, Gretchen E, Heckman, Michael G, White, Launia J, Roy, Vivek, Foran, James M
Format: Article
Language:English
Subjects:
Blood
Bone marrow
Cancer
Cancer patients
Cancer therapies
Care and treatment
Chemotherapy
Health aspects
Health-related quality of life (HRQOL)
Hematopoietic stem cell transplant
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Hormones
Hospitalization
Humans
Immune system
Immunology
Leukocytes
Likert scale
Loneliness
Lymphocytes
Missing data
Mortality
Neutrophils
Patient outcomes
Patients
Psychological aspects
Psychoneuroimmunology
Psychosocial oncology
Quality of Life
Ratios
Social aspects
Stem cell transplantation
Transplantation
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Summary:Loneliness may compromise health-related quality of life (HRQOL) outcomes and the immunological impacts of loneliness via neuroendocrinological mechanisms likely have consequences for patients who have undergone a hematopoietic stem cell transplantation (HSCT). Loneliness (pre-transplant), immunological recovery (Day 30, Day 100, 1-year post-transplant), and HRQOL (Day 100, 1 year) were measured in a sample of 205 patients completing a HSCT (127 autologous, 78 allogenic). Greater levels of pre-transplant loneliness predicted poorer HRQOL at Day 100 and 1-year follow-up. Loneliness also was associated with higher absolute neutrophil to absolute lymphocyte (ANC/ALC) ratios in the entire sample at Day 30, which in turn was associated with Day 100 HRQOL. Findings demonstrate that pretransplant loneliness predicts HRQOL outcomes and associates with inflammatory immunological recovery patterns in HSCT patients. The balance of innate neutrophils to adaptive lymphocytes at Day 30 present a distinct profile in lonely individuals, with this immunity recovery profile predicting reduced HRQOL 100 days after the transplant. Addressing perceptions of loneliness before HSCT may be an important factor in improving immunological recovery and HRQOL outcomes.
ISSN:2050-7283
2050-7283
DOI:10.1186/s40359-024-01535-w