Experimental encephalitis caused by Taenia crassiceps cysticerci in mice

To present the experimental model of neurocysticercosis (NCC) caused by Taenia crassiceps cysticerci, to describe the inflammatory process, susceptibility, or resistance of BALB/c and C57BL/6 mice to this infection, and to describe the host-parasite relationship. The animals were intracranially inoc...

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Bibliographic Details
Published in:Arquivos de neuro-psiquiatria 2012-04, Vol.70 (4), p.287-292
Main Authors: Matos-Silva, Hidelberto, Reciputti, Bruno Pereira, Paula, Elbio Cândido de, Oliveira, André Luiz, Moura, Vânia Beatriz Lopes, Vinaud, Marina Clare, Oliveira, Milton Adriano Pelli, Lino-Júnior, Ruy de Souza
Format: Article
Language:English
Subjects:
Animal models
Animals
BALB/c
C57BL/6
Classification
Cysticercosis
Disease Models, Animal
Encephalitis
Encephalitis - parasitology
Encephalitis - pathology
Female
Host-Parasite Interactions
Inflammation
Inoculation
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Necrosis
neurocisticercose
Neurocysticercosis - parasitology
Neurocysticercosis - pathology
NEUROSCIENCES
Parasites
PSYCHIATRY
Severity of Illness Index
Taenia
Taenia - physiology
Taenia crassiceps
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Summary:To present the experimental model of neurocysticercosis (NCC) caused by Taenia crassiceps cysticerci, to describe the inflammatory process, susceptibility, or resistance of BALB/c and C57BL/6 mice to this infection, and to describe the host-parasite relationship. The animals were intracranially inoculated with initial stage T. crassiceps cysticerci. They were euthanized at 7, 30, 60, and 90 days after the inoculation. Their encephala were removed for the histopathologic analysis, classification of the parasites, and inflammatory lesions. Experimental NCC was observed on both mice lineages. BALB/c mice presented inflammatory lesions with greater intensity, inducing necrosis on late stage parasites, and with an acute inflammation pattern, while C57BL/6 mice showed greater capability on provoking early necrosis in the cysticerci, which showed a chronic inflammation pattern. This experimental model induced NCC on mice with characteristic inflammation and lesions. C57BL/6 mice were able to induce precocious necrosis of the parasites presenting inflammatory lesions with lower intensity.
ISSN:0004-282X
1678-4227
1678-4227
DOI:10.1590/S0004-282X2012005000010