Preparation and Antioxidant Activity of Chitosan Dimers with Different Sequences

As a popular marine saccharide, chitooligosaccharides (COS) has been proven to have good antioxidant activity. Its antioxidant effect is closely related to its degree of polymerization, degree of acetylation and sequence. However, the specific structure–activity relationship remains unclear. In this...

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Bibliographic Details
Published in:Marine drugs 2021-06, Vol.19 (7), p.366
Main Authors: Hao, Wentong, Li, Kecheng, Ma, Yuzhen, Li, Rongfeng, Xing, Ronge, Yu, Huahua, Li, Pengcheng
Format: Article
Language:English
Subjects:
Acetylation
Amino groups
antioxidant activity
Antioxidants
biological method
Carbohydrates
Chitosan
chitosan dimers
Chromatography
Degree of polymerization
Dimers
Free radicals
Hydroxyl radicals
Molecular structure
Molecular weight
Oxidative stress
Polymerization
Saccharides
Scavenging
separation
sequence
Sequencing
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Summary:As a popular marine saccharide, chitooligosaccharides (COS) has been proven to have good antioxidant activity. Its antioxidant effect is closely related to its degree of polymerization, degree of acetylation and sequence. However, the specific structure–activity relationship remains unclear. In this study, three chitosan dimers with different sequences were obtained by the separation and enzymatic method, and the antioxidant activity of all four chitosan dimers were studied. The effect of COS sequence on its antioxidant activity was revealed for the first time. The amino group at the reducing end plays a vital role in scavenging superoxide radicals and in the reducing power of the chitosan dimer. At the same time, we found that the fully deacetylated chitosan dimer DD showed the strongest DPPH scavenging activity. When the amino groups of the chitosan dimer were acetylated, it showed better activity in scavenging hydroxyl radicals. Research on COS sequences opens up a new path for the study of COS, and is more conducive to the investigation of its mechanism.
ISSN:1660-3397
1660-3397
DOI:10.3390/md19070366