P-Cadherin Expression in Feline Mammary Tissues

The search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans. To study P-cadherin expression in the feline mammary gland, 61 samples of norm...

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Bibliographic Details
Published in:Veterinary Medicine International 2012, Vol.2012 (2012), p.390-396
Main Authors: Figueira, Ana Catarina, Teodósio, Ana Sofia, Carvalheira, Júlio, Lacerda, Manuela, de Matos, Augusto, Gärtner, Fátima
Format: Article
Language:English
Subjects:
Breast cancer
Cadherins
Development and progression
Gene expression
Genetic aspects
Physiological aspects
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Summary:The search for molecular markers in the feline mammary gland, namely, the adhesion molecules belonging to the cadherin family, is useful in the understanding of the development of mammary carcinomas in felines and humans. To study P-cadherin expression in the feline mammary gland, 61 samples of normal (n=4), hyperplastic (n=12), and neoplastic (n=45) feline mammary tissues were examined. In both normal and hyperplastic mammary tissues as well as in benign tumours, P-cadherin immunolabelling was restricted to myoepithelial cells. In malignant tumours, however, there was an aberrant epithelial P-cadherin immunoexpression in 64.1% (n=25) of cases, with a membranous and/or cytoplasmic pattern of distribution. A statistically significant relationship was seen between epithelial P-cadherin expression and malignant mammary lesions (P=0.0001). In malignant mammary tumours, there was likewise a statistically significant relationship between aberrant P-cadherin immunoexpression and histological grade (P=0.0132). Aberrant epithelial P-cadherin expression seems to be related to malignancy in the feline mammary gland. To confirm the results of this investigation, further studies with larger samples and follow-up studies are warranted.
ISSN:2090-8113
2042-0048
2042-0048
DOI:10.1155/2012/687424