Antibacterial Activities and Underlying Mechanisms of the Compound SYAUP-491 against Xanthomonas oryzae pv. oryzae

• Published in: Molecules (Basel, Switzerland) Switzerland), 2024-03, Vol.29 (6), p.1413
• Main Authors: Li, Lina, Wang, Yuxin, Liu, He, Liu, Wei, Zhang, Xinchen, An, Mengnan, Yu, Miao, Wu, Yuanhua, Li, Xinghai, Wang, Jianzhong
• Format: Article
• Language: English
• Subjects: Agriculture; alkyl sulfonamide; Anti-Bacterial Agents - pharmacology; antibacterial activity; Antibiotics; Bacteria; Bacterial infections; Drug resistance; Herbicides; mechanism; Microbial Sensitivity Tests; Microscopy; Oryza - microbiology; Permeability; Plant diseases; Plant Diseases - microbiology; Plant Diseases - prevention & control; Proteins; Proteomics; Rice; Sulfonamides; Toxicity; Xanthomonas; Xanthomonas oryzae pv. oryzae
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29061413

SYAUP-491 is a novel alkyl sulfonamide. In this study, in vivo and in vitro tests were performed along with a proteomic analysis to determine the effects and underlying mechanisms of the antibacterial activity of SYAUP-491 against the causative agent of bacterial leaf blight in rice. The antibacterial test results suggested that SYAUP-491 exhibited significant activities against pv. (Xoo) in vitro and in vivo. The minimal EC values reached 6.96 μg/mL and the curative activity reached 74.1%. Detailed studies demonstrated that SYAUP-491 altered membrane permeability and caused morphological changes. Based on proteomics results, SYAUP-491 might inhibit bacterial protein synthesis. SYAUP-491 may disrupt and alter cell membrane permeability and could further act on ribosomes in the bacterial body. Given the above results, SYAUP-491 could serve as a new lead compound in the research of antibacterial control of plant pathogenic bacterial disease.