Antibacterial Activities and Underlying Mechanisms of the Compound SYAUP-491 against Xanthomonas oryzae pv. oryzae

SYAUP-491 is a novel alkyl sulfonamide. In this study, in vivo and in vitro tests were performed along with a proteomic analysis to determine the effects and underlying mechanisms of the antibacterial activity of SYAUP-491 against the causative agent of bacterial leaf blight in rice. The antibacteri...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2024-03, Vol.29 (6), p.1413
Main Authors: Li, Lina, Wang, Yuxin, Liu, He, Liu, Wei, Zhang, Xinchen, An, Mengnan, Yu, Miao, Wu, Yuanhua, Li, Xinghai, Wang, Jianzhong
Format: Article
Language:English
Subjects:
Agriculture
alkyl sulfonamide
Anti-Bacterial Agents - pharmacology
antibacterial activity
Antibiotics
Bacteria
Bacterial infections
Drug resistance
Herbicides
mechanism
Microbial Sensitivity Tests
Microscopy
Oryza - microbiology
Permeability
Plant diseases
Plant Diseases - microbiology
Plant Diseases - prevention & control
Proteins
Proteomics
Rice
Sulfonamides
Toxicity
Xanthomonas
Xanthomonas oryzae pv. oryzae
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container_issue 6
container_start_page 1413
container_title Molecules (Basel, Switzerland)
container_volume 29
creator Li, Lina
Wang, Yuxin
Liu, He
Liu, Wei
Zhang, Xinchen
An, Mengnan
Yu, Miao
Wu, Yuanhua
Li, Xinghai
Wang, Jianzhong
description SYAUP-491 is a novel alkyl sulfonamide. In this study, in vivo and in vitro tests were performed along with a proteomic analysis to determine the effects and underlying mechanisms of the antibacterial activity of SYAUP-491 against the causative agent of bacterial leaf blight in rice. The antibacterial test results suggested that SYAUP-491 exhibited significant activities against pv. (Xoo) in vitro and in vivo. The minimal EC values reached 6.96 μg/mL and the curative activity reached 74.1%. Detailed studies demonstrated that SYAUP-491 altered membrane permeability and caused morphological changes. Based on proteomics results, SYAUP-491 might inhibit bacterial protein synthesis. SYAUP-491 may disrupt and alter cell membrane permeability and could further act on ribosomes in the bacterial body. Given the above results, SYAUP-491 could serve as a new lead compound in the research of antibacterial control of plant pathogenic bacterial disease.
doi_str_mv 10.3390/molecules29061413
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In this study, in vivo and in vitro tests were performed along with a proteomic analysis to determine the effects and underlying mechanisms of the antibacterial activity of SYAUP-491 against the causative agent of bacterial leaf blight in rice. The antibacterial test results suggested that SYAUP-491 exhibited significant activities against pv. (Xoo) in vitro and in vivo. The minimal EC values reached 6.96 μg/mL and the curative activity reached 74.1%. Detailed studies demonstrated that SYAUP-491 altered membrane permeability and caused morphological changes. Based on proteomics results, SYAUP-491 might inhibit bacterial protein synthesis. SYAUP-491 may disrupt and alter cell membrane permeability and could further act on ribosomes in the bacterial body. 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subjects Agriculture
alkyl sulfonamide
Anti-Bacterial Agents - pharmacology
antibacterial activity
Antibiotics
Bacteria
Bacterial infections
Drug resistance
Herbicides
mechanism
Microbial Sensitivity Tests
Microscopy
Oryza - microbiology
Permeability
Plant diseases
Plant Diseases - microbiology
Plant Diseases - prevention & control
Proteins
Proteomics
Rice
Sulfonamides
Toxicity
Xanthomonas
Xanthomonas oryzae pv. oryzae
title Antibacterial Activities and Underlying Mechanisms of the Compound SYAUP-491 against Xanthomonas oryzae pv. oryzae
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