Effective use of intensive treatment against multiple myeloma of recipient origin after allogeneic transplantation for acute myeloid leukemia

We describe here a 56-years –old woman cured in our institution for an acute myeloid leukemia (AML) and a monoclonal gammopathy of undetermined significance (MGUS). In order to treat AML, underwent allogeneic stem cell transplantation in second complete remission. Four years after transplant, MGUS e...

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Bibliographic Details
Published in:Leukemia research reports 2023-01, Vol.19, p.100366, Article 100366
Main Authors: de Charry, Félicité, Konopacki, Johanna, Bugier, Sarah, Foissaud, Vincent, Sloma, Ivan, Malfuson, Jean-Valère, Arnautou, Pierre
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Allogeneic hematopoietic stem cell transplantation
Autologous hematopoietic stem cell transplantation
Multiple myeloma
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Summary:We describe here a 56-years –old woman cured in our institution for an acute myeloid leukemia (AML) and a monoclonal gammopathy of undetermined significance (MGUS). In order to treat AML, underwent allogeneic stem cell transplantation in second complete remission. Four years after transplant, MGUS evolved to multiple myeloma and was intensively treated with “autologous” transplant after successful mobilization. This report illustrates: (i) a lack of efficacy of graft versus myeloma effect in a patient probably cured of AML by graft versus leukaemia effect; (ii) the ability to mobilize peripheral blood stem cells in order to perform “autologous” transplantation after allogeneic transplantation.
ISSN:2213-0489
2213-0489
DOI:10.1016/j.lrr.2023.100366