Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation

• Published in: Scientific reports 2021-03, Vol.11 (1), p.6847-6847, Article 6847
• Main Authors: Enomoto, Nobuko, Anraku, Ayako, Tomita, Goji, Iwase, Aiko, Sato, Takashi, Shoji, Nobuyuki, Shiba, Tomoaki, Nakazawa, Toru, Sugiyama, Kazuhisa, Nitta, Koji, Araie, Makoto
• Format: Article
• Language: English
• Subjects: 631/443/1338/2729; 692/308; Age; Atrophy; Blood pressure; Body mass index; Confidence intervals; Flow velocity; Gender; Glaucoma; Heart rate; Humanities and Social Sciences; Lasers; multidisciplinary; Ophthalmology; Optic nerve; Regression analysis; Retina; Science; Science (multidisciplinary); Veins & arteries
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-86280-5

To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and MV, respectively), and MT and MV pulse waveform parameters were obtained using LSFG and ONH structural parameters using planimetry. Multivariate linear mixed-effects modeled regression analysis identified factors contributing to MT- or MV-waveforms using age, gender, smoking history, body mass index, systolic and diastolic blood pressure, heart rate, intraocular pressure, axial length, disc, rim, and β-peripapillary atrophy areas, MT or MV, central retinal artery, and vein equivalents (CRAE and CRVE) as explanatory variables. MT- and MV-waveforms significantly correlated with one or more systemic factors, consistent with previous studies. Following confounding factor adjustment, MT-Skew significantly negatively correlated with β-PPA area ( P  = 0.026); MT- and MV-flow acceleration index positively correlated with CRAE, MT, and MV ( P  = 0.041–