Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines

Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine a...

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Published in:Memórias do Instituto Oswaldo Cruz 2010-11, Vol.105 (7), p.908-913
Main Authors: Fischer, Geferson, Paulino, Niraldo, Marcucci, Maria C, Siedler, Bianca S, Munhoz, Lívia S, Finger, Paula F, Vargas, Gilberto D, Hübner, Sílvia O, Vidor, Telmo, Roehe, Paulo M
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Antibodies, Viral - immunology
cellular immunity
Herpesvirus 1, Suid - immunology
Herpesvirus Vaccines - immunology
humoral immunity
Immunity, Cellular - immunology
Immunity, Humoral - immunology
Mice
Mice, Inbred BALB C
PARASITOLOGY
phenolic compounds
propolis
Propolis - chemistry
propolis - phenolic compounds - vaccines - humoral immunity - cellular immunity
Pseudorabies - immunology
Pseudorabies - prevention & control
Swine
TROPICAL MEDICINE
vaccines
Vaccines, Inactivated - immunology
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Summary:Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity.
ISSN:1678-8060
0074-0276
1678-8060
0074-0276
DOI:10.1590/S0074-02762010000700012