Beta‐Blocker Use Is Associated With Impaired Left Atrial Function in Hypertension

Background Impaired left atrial (LA) mechanical function is present in hypertension and likely contributes to various complications, including atrial arrhythmias, stroke, and heart failure. Various antihypertensive drug classes exert differential effects on central hemodynamics and left ventricular...

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Bibliographic Details
Published in:Journal of the American Heart Association 2017-02, Vol.6 (2), p.n/a
Main Authors: Sardana, Mayank, Syed, Amer Ahmed, Hashmath, Zeba, Phan, Timothy S., Koppula, Maheswara R., Kewan, Uzma, Ahmed, Zoubair, Chandamuri, Ravikantha, Varakantam, Swapna, Shah, Ejaz, Gorz, Ryan, Akers, Scott R., Chirinos, Julio A.
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
angiotensin‐converting enzyme inhibitors
Antihypertensive Agents - therapeutic use
Atrial Function, Left - drug effects
Atrial Function, Left - physiology
Blood Pressure Determination - methods
Female
Heart Atria - diagnostic imaging
Heart Atria - drug effects
Heart Atria - physiopathology
Humans
hypertension
Hypertension - diagnosis
Hypertension - drug therapy
Hypertension - physiopathology
left atrium
magnetic resonance imaging
Magnetic Resonance Imaging, Cine - methods
Male
Middle Aged
Original Research
Stroke Volume - drug effects
β‐adrenergic antagonists
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Summary:Background Impaired left atrial (LA) mechanical function is present in hypertension and likely contributes to various complications, including atrial arrhythmias, stroke, and heart failure. Various antihypertensive drug classes exert differential effects on central hemodynamics and left ventricular function. However, little is known about their effects on LA function. Methods and Results We studied 212 subjects with hypertension and without heart failure or atrial fibrillation. LA strain was measured from cine steady‐state free‐precession cardiac MRI images using feature‐tracking algorithms. In multivariable models adjusted for age, sex, race, body mass index, blood pressure, diabetes mellitus, LA volume, left ventricular mass, and left ventricular ejection fraction, beta‐blocker use was associated with a lower total longitudinal strain (standardized β=−0.21; P=0.008), and lower LA expansion index (standardized β=−0.30; P
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.116.005163