Metabolomics in Radiation-Induced Biological Dosimetry: A Mini-Review and a Polyamine Study

In this study, we elucidate that polyamine metabolite is a powerful biomarker to study post-radiation changes. Metabolomics in radiation biodosimetry, the application of a metabolomics analysis to the field of radiobiology, promises to increase the understanding of biological responses by ionizing r...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2018-05, Vol.8 (2), p.34
Main Author: Roh, Changhyun
Format: Article
Language:English
Subjects:
Animals
biomarker
Biomarkers
Biomarkers - metabolism
Biosensing Techniques - methods
Cell growth
Dosimetry
Humans
Ionizing radiation
Metabolites
Metabolome - radiation effects
Metabolomics
Metabolomics - methods
NMR
Nuclear magnetic resonance
polyamines
Polyamines - metabolism
Post-radiation
radiation biodosimetry
Radiation Injuries - metabolism
Radiation, Ionizing
Radiometry - methods
Review
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Summary:In this study, we elucidate that polyamine metabolite is a powerful biomarker to study post-radiation changes. Metabolomics in radiation biodosimetry, the application of a metabolomics analysis to the field of radiobiology, promises to increase the understanding of biological responses by ionizing radiation (IR). Radiation exposure triggers a complex network of molecular and cellular responses that impacts metabolic processes and alters the levels of metabolites. Such metabolites have potential as biomarkers for radiation dosimetry. Among metabolites, polyamine is one of many potential biomarkers to estimate radiation response. In addition, this review provides an opportunity for the understanding of a radiation metabolomics in biodosimetry and a polyamine case study.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom8020034