Role of Neddylation in Neurodegenerative Diseases

Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An essential mechanism for regulating the clearance o...

Full description

Saved in:
Bibliographic Details
Published in:NeuroSci 2022-12, Vol.3 (4), p.533-545
Main Authors: Govindarajulu, Manoj, Ramesh, Sindhu, Shankar, Tharanth, Kora, Murali Krishna, Moore, Timothy, Dhanasekaran, Muralikrishnan
Format: Article
Language:English
Subjects:
Alzheimer’s disease
misfolded proteins
NEDD8
neddylation
neurodegenerative diseases
Parkinson’s disease
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c390t-478982705071d4d49d7f7a5e7252d8ef788c40c0ed70dc881d88a2c59a7fadc53
cites cdi_FETCH-LOGICAL-c390t-478982705071d4d49d7f7a5e7252d8ef788c40c0ed70dc881d88a2c59a7fadc53
container_end_page 545
container_issue 4
container_start_page 533
container_title NeuroSci
container_volume 3
creator Govindarajulu, Manoj
Ramesh, Sindhu
Shankar, Tharanth
Kora, Murali Krishna
Moore, Timothy
Dhanasekaran, Muralikrishnan
description Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An essential mechanism for regulating the clearance of misfolded proteins is neddylation, a post-translational modification closely related to ubiquitination. Neddylation is brought about by conjugating neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to target substrates through a cascade of cellular events. Neddylation is crucial for many biological processes, and dysfunctional neddylation is implicated in several neurodegenerative diseases. This review discusses the current understanding of the role of neddylation pathways in neurodegenerative disorders and the emergence of neddylation signaling as a potential target for drug discovery and development in neurodegenerative diseases.
doi_str_mv 10.3390/neurosci3040038
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_0e215285fa8c451d9551a9a09333f97b</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_0e215285fa8c451d9551a9a09333f97b</doaj_id><sourcerecordid>3123076073</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-478982705071d4d49d7f7a5e7252d8ef788c40c0ed70dc881d88a2c59a7fadc53</originalsourceid><addsrcrecordid>eNpdkUtPWzEQhS1URBCwZldl2U3I2GPH9qqq6CsSaiUEa8vYc4PRzTW1b5Dy7zEEEHQ1rzPfjHQYO-VwhmhhPtCm5BoSggRAs8cOxULjTILRn97lE3ZS6x0ACMWFRHnAJmilQa35IeOXuadp7qZ_KMZt78eUh2kaWtnYkVY0UGnNB5p-T5V8pXrM9jvfVzp5iUfs-uePq_Pfs4u_v5bn3y5mof02zqQ21ggNCjSPMkobdae9Ii2UiIY6bUyQEICihhiM4dEYL4KyXnc-BoVHbLnjxuzv3H1Ja1-2Lvvknhu5rJwvYwo9OSDBlTCq842peLRKcW89WETsrL5prK871v3mZk0x0DAW33-AfpwM6dat8oPjjYsLKxvhywuh5H8bqqNbpxqo7_1AeVMdcoGgF6CxSec7aWju1ELd2x0O7sk4959xbePz-_fe9K824SOw1pTI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3123076073</pqid></control><display><type>article</type><title>Role of Neddylation in Neurodegenerative Diseases</title><source>PubMed Central (Open access)</source><source>DOAJ Directory of Open Access Journals</source><creator>Govindarajulu, Manoj ; Ramesh, Sindhu ; Shankar, Tharanth ; Kora, Murali Krishna ; Moore, Timothy ; Dhanasekaran, Muralikrishnan</creator><creatorcontrib>Govindarajulu, Manoj ; Ramesh, Sindhu ; Shankar, Tharanth ; Kora, Murali Krishna ; Moore, Timothy ; Dhanasekaran, Muralikrishnan</creatorcontrib><description>Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An essential mechanism for regulating the clearance of misfolded proteins is neddylation, a post-translational modification closely related to ubiquitination. Neddylation is brought about by conjugating neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to target substrates through a cascade of cellular events. Neddylation is crucial for many biological processes, and dysfunctional neddylation is implicated in several neurodegenerative diseases. This review discusses the current understanding of the role of neddylation pathways in neurodegenerative disorders and the emergence of neddylation signaling as a potential target for drug discovery and development in neurodegenerative diseases.</description><identifier>ISSN: 2673-4087</identifier><identifier>EISSN: 2673-4087</identifier><identifier>DOI: 10.3390/neurosci3040038</identifier><identifier>PMID: 39483771</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Alzheimer’s disease ; misfolded proteins ; NEDD8 ; neddylation ; neurodegenerative diseases ; Parkinson’s disease ; Review</subject><ispartof>NeuroSci, 2022-12, Vol.3 (4), p.533-545</ispartof><rights>2022 by the authors.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-478982705071d4d49d7f7a5e7252d8ef788c40c0ed70dc881d88a2c59a7fadc53</citedby><cites>FETCH-LOGICAL-c390t-478982705071d4d49d7f7a5e7252d8ef788c40c0ed70dc881d88a2c59a7fadc53</cites><orcidid>0000-0003-4739-648X ; 0000-0001-8986-3440</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523694/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523694/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39483771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Govindarajulu, Manoj</creatorcontrib><creatorcontrib>Ramesh, Sindhu</creatorcontrib><creatorcontrib>Shankar, Tharanth</creatorcontrib><creatorcontrib>Kora, Murali Krishna</creatorcontrib><creatorcontrib>Moore, Timothy</creatorcontrib><creatorcontrib>Dhanasekaran, Muralikrishnan</creatorcontrib><title>Role of Neddylation in Neurodegenerative Diseases</title><title>NeuroSci</title><addtitle>NeuroSci</addtitle><description>Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An essential mechanism for regulating the clearance of misfolded proteins is neddylation, a post-translational modification closely related to ubiquitination. Neddylation is brought about by conjugating neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to target substrates through a cascade of cellular events. Neddylation is crucial for many biological processes, and dysfunctional neddylation is implicated in several neurodegenerative diseases. This review discusses the current understanding of the role of neddylation pathways in neurodegenerative disorders and the emergence of neddylation signaling as a potential target for drug discovery and development in neurodegenerative diseases.</description><subject>Alzheimer’s disease</subject><subject>misfolded proteins</subject><subject>NEDD8</subject><subject>neddylation</subject><subject>neurodegenerative diseases</subject><subject>Parkinson’s disease</subject><subject>Review</subject><issn>2673-4087</issn><issn>2673-4087</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpdkUtPWzEQhS1URBCwZldl2U3I2GPH9qqq6CsSaiUEa8vYc4PRzTW1b5Dy7zEEEHQ1rzPfjHQYO-VwhmhhPtCm5BoSggRAs8cOxULjTILRn97lE3ZS6x0ACMWFRHnAJmilQa35IeOXuadp7qZ_KMZt78eUh2kaWtnYkVY0UGnNB5p-T5V8pXrM9jvfVzp5iUfs-uePq_Pfs4u_v5bn3y5mof02zqQ21ggNCjSPMkobdae9Ii2UiIY6bUyQEICihhiM4dEYL4KyXnc-BoVHbLnjxuzv3H1Ja1-2Lvvknhu5rJwvYwo9OSDBlTCq842peLRKcW89WETsrL5prK871v3mZk0x0DAW33-AfpwM6dat8oPjjYsLKxvhywuh5H8bqqNbpxqo7_1AeVMdcoGgF6CxSec7aWju1ELd2x0O7sk4959xbePz-_fe9K824SOw1pTI</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Govindarajulu, Manoj</creator><creator>Ramesh, Sindhu</creator><creator>Shankar, Tharanth</creator><creator>Kora, Murali Krishna</creator><creator>Moore, Timothy</creator><creator>Dhanasekaran, Muralikrishnan</creator><general>MDPI</general><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4739-648X</orcidid><orcidid>https://orcid.org/0000-0001-8986-3440</orcidid></search><sort><creationdate>20221201</creationdate><title>Role of Neddylation in Neurodegenerative Diseases</title><author>Govindarajulu, Manoj ; Ramesh, Sindhu ; Shankar, Tharanth ; Kora, Murali Krishna ; Moore, Timothy ; Dhanasekaran, Muralikrishnan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-478982705071d4d49d7f7a5e7252d8ef788c40c0ed70dc881d88a2c59a7fadc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer’s disease</topic><topic>misfolded proteins</topic><topic>NEDD8</topic><topic>neddylation</topic><topic>neurodegenerative diseases</topic><topic>Parkinson’s disease</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Govindarajulu, Manoj</creatorcontrib><creatorcontrib>Ramesh, Sindhu</creatorcontrib><creatorcontrib>Shankar, Tharanth</creatorcontrib><creatorcontrib>Kora, Murali Krishna</creatorcontrib><creatorcontrib>Moore, Timothy</creatorcontrib><creatorcontrib>Dhanasekaran, Muralikrishnan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>NeuroSci</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Govindarajulu, Manoj</au><au>Ramesh, Sindhu</au><au>Shankar, Tharanth</au><au>Kora, Murali Krishna</au><au>Moore, Timothy</au><au>Dhanasekaran, Muralikrishnan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Neddylation in Neurodegenerative Diseases</atitle><jtitle>NeuroSci</jtitle><addtitle>NeuroSci</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>3</volume><issue>4</issue><spage>533</spage><epage>545</epage><pages>533-545</pages><issn>2673-4087</issn><eissn>2673-4087</eissn><abstract>Neurodegenerative diseases are characterized by progressive loss of neurons in specific regions of the brain. Neuronal death is often associated with the accumulation of misfolded proteins due to genetic mutations or abnormal protein homeostasis. An essential mechanism for regulating the clearance of misfolded proteins is neddylation, a post-translational modification closely related to ubiquitination. Neddylation is brought about by conjugating neural precursor cell-expressed developmentally downregulated protein 8 (NEDD8) to target substrates through a cascade of cellular events. Neddylation is crucial for many biological processes, and dysfunctional neddylation is implicated in several neurodegenerative diseases. This review discusses the current understanding of the role of neddylation pathways in neurodegenerative disorders and the emergence of neddylation signaling as a potential target for drug discovery and development in neurodegenerative diseases.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>39483771</pmid><doi>10.3390/neurosci3040038</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4739-648X</orcidid><orcidid>https://orcid.org/0000-0001-8986-3440</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2673-4087
ispartof NeuroSci, 2022-12, Vol.3 (4), p.533-545
issn 2673-4087
2673-4087
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_0e215285fa8c451d9551a9a09333f97b
source PubMed Central (Open access); DOAJ Directory of Open Access Journals
subjects Alzheimer’s disease
misfolded proteins
NEDD8
neddylation
neurodegenerative diseases
Parkinson’s disease
Review
title Role of Neddylation in Neurodegenerative Diseases
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T14%3A49%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20Neddylation%20in%20Neurodegenerative%20Diseases&rft.jtitle=NeuroSci&rft.au=Govindarajulu,%20Manoj&rft.date=2022-12-01&rft.volume=3&rft.issue=4&rft.spage=533&rft.epage=545&rft.pages=533-545&rft.issn=2673-4087&rft.eissn=2673-4087&rft_id=info:doi/10.3390/neurosci3040038&rft_dat=%3Cproquest_doaj_%3E3123076073%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c390t-478982705071d4d49d7f7a5e7252d8ef788c40c0ed70dc881d88a2c59a7fadc53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3123076073&rft_id=info:pmid/39483771&rfr_iscdi=true