Altered Glycosylation in Progression and Management of Bladder Cancer

Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of BC patients. Therefore, there is a need to deep...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-04, Vol.28 (8), p.3436
Main Authors: Wilczak, Magdalena, Surman, Magdalena, Przybyło, Małgorzata
Format: Article
Language:English
Subjects:
Angiogenesis
Antigen (tumor-associated)
Antigens
Antigens, Tumor-Associated, Carbohydrate
Apoptosis
Biological activity
Biosynthesis
Bladder cancer
Canada
Cancer
Carbohydrates
Cell surface
Development and progression
Epithelial Cells - metabolism
Extracellular matrix
extracellular vesicles
Genes
Glycan
Glycoproteins
glycosaminoglycans
Glycosylation
Health aspects
Humans
Lewis’s antigen
Malignancy
Medical prognosis
Melanoma
Metastases
Metastasis
Molecular modelling
Mortality
mucins
N-glycosylation
Peptides
Physiological aspects
Physiology
Polysaccharides
Polysaccharides - metabolism
Proteins
Review
Therapeutic applications
Tumors
Urinary Bladder Neoplasms - pathology
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Summary:Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of BC patients. Therefore, there is a need to deepen our understanding of the molecular mechanisms underlying BC progression to develop new diagnostic and therapeutic tools. One such mechanism is protein glycosylation. Numerous studies reported changes in glycan biosynthesis during neoplastic transformation, resulting in the appearance of the so-called tumor-associated carbohydrate antigens (TACAs) on the cell surface. TACAs affect a wide range of key biological processes, including tumor cell survival and proliferation, invasion and metastasis, induction of chronic inflammation, angiogenesis, immune evasion, and insensitivity to apoptosis. The purpose of this review is to summarize the current information on how altered glycosylation of bladder cancer cells promotes disease progression and to present the potential use of glycans for diagnostic and therapeutic purposes.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28083436