Bioinformatic exploration of OLFML2B overexpression in gastric cancer base on multiple analyzing tools

• Published in: BMC cancer 2019-03, Vol.19 (1), p.227-227, Article 227
• Main Authors: Liu, Jiaxin, Liu, Zhao, Zhang, Xiaozhi, Gong, Tuotuo, Yao, Demao
• Format: Article
• Language: English
• Subjects: Aged; Apoptosis; Bcl-2 protein; Bioinformatic; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Breast cancer; Cancer; Cancer genetics; Cancer patients; Care and treatment; Cell cycle; Cell interactions; Computational Biology - methods; Databases, Genetic; Diagnosis; DNA; DNA biosynthesis; DNA replication; ErbB-2 protein; ERCC1 protein; Extracellular Matrix Proteins - biosynthesis; Extracellular Matrix Proteins - genetics; Female; Gastric cancer; Gastrointestinal diseases; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Genomes; Genomics; Glycoproteins - biosynthesis; Glycoproteins - genetics; Growth factors; Health aspects; Humans; Immunohistochemistry; Male; Medical prognosis; Messenger RNA; Middle Aged; Missense mutation; Novels; Olfactomedin; OLFML2B; Post-translation; Post-translational modifications; Prognosis; Proteins; Replication initiation; RNA; Stomach cancer; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Survival analysis; Tumors
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-019-5406-x

Gastric cancer (GC) is one of the most commonly occuring gastrointestinal tumor types, and early diagnosis and operation have a notable effect on the prognosis of patients. Although certain markers, including HER2, VEGER-2, ERCC1 and Bcl-2, have been utilized in clinical practise to screen out new patients with GC, the results of using these markers remains poor. The role of olfactomedin-like 2B (OLFML2B) in GC, as a member of the olfactomedin domain-containing proteins family, is remain unclear. In the present study, we assessed the expression of OLFML2B, including mRNA and protein level, by using The Cancer Genome Atlas (TCGA) database and 13 pairs of clinical samples between GC and NG tissues. The correlation between expression of OLFML2B and prognosis of GC was evaculated by the Kaplan-Meier plotter and OncoLnc online tools. In addition, mechanism analysis of OLFML2B in GC was explored thought bioinformatic tools, including cBioPortal and FunRich software. In our study, the mRNA expression of OLFML2B in GC both TCGA database and clinical samples was consistently revealed to be significantly higher compared with that in NG tissues (P